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Dapagliflozin is Well Tolerated in Hospitalized COVID-19 Patients

Dapagliflozin is Well Tolerated in Hospitalized COVID-19 Patients
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Dapagliflozin Did Not Significantly Reduce Organ Failure or Death in High-Risk Hospitalized COVID-19 Patients

Dapagliflozin Did Not Significantly Reduce Organ Failure or Death in High-Risk Hospitalized COVID-19 Patients
Phase III DARE-19 trial shows SGLT2 inhibitor is well-tolerated in acutely ill patients
Dapagliflozin did not significantly reduce organ failure or death in high-risk hospitalized COVID-19 patients in the DARE-19 trial results, presented at ACC.21.
May 18, 2021 Dapagliflozin (Farxiga), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, did not significantly reduce the risk of organ failure or death or improve recovery in patients hospitalized with COVID-19 (SARS-CoV-2) who are at high risk of developing serious complications compared to placebo, according to data presented at the American College of Cardiology (ACC) 2021 Scientific Session. ....

Dapagliflozin Farxiga , Mikhail Kosiborod , Research At Saint Luke Health System , Saint Luke Mid America Heart Institute , American College Of Cardiology , American College , Respiratory Failure , Saint Luke , Mid America Heart Institute , Health System , Kansas City , ஆராய்ச்சி இல் துறவி லூக் ஆரோக்கியம் அமைப்பு , துறவி லூக் நடுவில் அமெரிக்கா இதயம் நிறுவனம் , அமெரிக்கன் கல்லூரி ஆஃப் இருதயவியல் , அமெரிக்கன் கல்லூரி , சுவாச தோல்வி , துறவி லூக் , நடுவில் அமெரிக்கா இதயம் நிறுவனம் , ஆரோக்கியம் அமைப்பு , கன்சாஸ் நகரம் ,

Dapagliflozin did not significantly reduce organ failure or death in high-risk patients hospitalized

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Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, did not significantly reduce the risk of organ failure or death or improve recovery in patients hospitalized with COVID-19 who are at high risk of developing serious complications compared to placebo, according to data presented at the American College of Cardiology s 70th Annual Scientific Session. The researchers, while acknowledging the results were not statistically significant, said they were encouraged by the lower numbers of organ failure and deaths observed in patients treated with dapagliflozin and by favorable safety data.
COVID-19 can lead to multi-organ failure, especially in patients at high risk for severe illness and complications. The Dapagliflozin in Respiratory Failure in Patients with COVID-19 (DARE-19) trial was the first phase III randomized, controlled clinical trial that was initiated to determine whether dapagliflozin could reduce cardiovascular, kidney and respiratory comp ....

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First patient enrolled in CARE-HK in HF to evaluate role of Veltassa® (patiromer) in enabling RAASi treatment

Regulatory News:
Vifor Pharma today announced that the first patient has been enrolled in the large scale registry CARE-HK in HF (cardiovascular and renal treatment in HF patients with or at high risk for HK). This non-interventional clinical study aims to better understand renin-angiotensin-aldosterone system inhibitors (RAASi) treatment decisions in clinical practice, potential barriers to achieving optimal guideline-directed care in HF patients with or at high risk for HK, and to assess how Veltassa Â® may be used in the management of this patient population.
âOne of the most pressing issues in management of chronic heart failure is that therapies that have proven to reduce the risk of death and hospitalizations, and are thus strongly recommended by the guidelines, are not optimally used in clinical practice. This is certainly the case with RAASi, which are under-used in many patients, especially those with or at high risk of hyperkalemia,â said Dr. Mikhail ....

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Vifor Pharma: First patient enrolled in CARE-HK in HF to evaluate role of Veltassa (patiromer) in enabling RAASi treatment

Vifor Pharma: First patient enrolled in CARE-HK in HF to evaluate role of Veltassa (patiromer) in enabling RAASi treatment
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