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Common brain malformation traced to its genetic roots – Washington University School of Medicine in St. Louis


David Limbrick
The lowest part of a child s brain is visible below the bottom of the skull in this MRI scan and shows evidence of a Chiari 1 malformation. Researchers at Washington University School of Medicine in St. Louis have shown that Chiari 1 malformation can be caused by variations in two genes linked to brain development, and that children with large heads are at increased risk of developing the condition.
About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances, or other neurological symptoms. ....

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Brain protein indicates a link between circadian rhythm dysfunction and Alzheimer's Disease


Brain protein indicates a link between circadian rhythm dysfunction and Alzheimer s Disease
Fractured sleep, daytime sleepiness and other signs of disturbance in one s circadian rhythm are common complaints of people with Alzheimer s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer s and circadian dysfunction is not well understood.
Researchers at Washington University School of Medicine in St. Louis say that a clue may lie in the brain protein YKL-40.
In a study published Dec. 16 in Science Translational Medicine, the researchers report that YKL-40 is both regulated by clock genes and involved in clearing away potentially toxic buildup of Alzheimer s proteins in the brain. Moreover, Alzheimer s patients who carry a genetic variant that reduces YKL-40 levels maintain their cognitive faculties longer than people without the variant, the scientists found. ....

Brianv Lananna , Erik Musiek , David Holtzman , Carlos Cruchaga , Gretchenp Jones , Anne Fagan , Emily Henderson , Researchers At Washington University School Of Medicine , Department Of Neurology , Joanne Knight Alzheimer Disease Research Center , Washington University In St , Washington University School , Science Translational Medicine , Study Senior Author , Associate Professor , Washington University , Joanne Knight Alzheimer , Disease Research , டேவிட் ஹோல்ட்ஸ்மேன் , அன்னே ஃபாகன் , எமிலி ஹென்டர்சன் , ஆராய்ச்சியாளர்கள் இல் வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , துறை ஆஃப் நரம்பியல் , ஜொவந் நைட் முதுமறதி நோய் ஆராய்ச்சி மையம் , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ,

Protein involved in removing Alzheimer's buildup linked to circadian rhythm | The Source


Brain protein helps explain link between circadian rhythm, Alzheimer’s disease
December 16, 2020
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Immune cells known as microglia (turquoise with red dots) surround a plaque of the Alzheimer’s protein amyloid (blue). The red dots indicate that the microglia are prepared to remove the potentially damaging plaque. Researchers at Washington University School of Medicine in St. Louis have discovered a protein that links the amyloid-removal process to the circadian clock. The protein, YKL-40, could help explain why people with Alzheimer’s frequently suffer from sleep disturbances, and provide a new target for Alzheimer’s therapies. (Image: Brian Lananna/School of Medicine) ....

Brianv Lananna , Erik Musiek , David Holtzman , Gretchenp Jones , Carlos Cruchaga , Anne Fagan , Brian Lananna School Of Medicine , Researchers At Washington University School Of Medicine , Department Of Neurology , Joanne Knight Alzheimer Disease Research Center , Washington University School , Science Translational Medicine , Joanne Knight Alzheimer , Disease Research , டேவிட் ஹோல்ட்ஸ்மேன் , அன்னே ஃபாகன் , ஆராய்ச்சியாளர்கள் இல் வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , துறை ஆஃப் நரம்பியல் , ஜொவந் நைட் முதுமறதி நோய் ஆராய்ச்சி மையம் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , அறிவியல் மொழிபெயர்ப்பு மருந்து , ஜொவந் நைட் முதுமறதி , நோய் ஆராய்ச்சி ,

Protein involved in removing Alzheimer's buildup linked to circadian rhythm

Higher Education Grants or Gifts of Interest to African Americans : The Journal of Blacks in Higher Education


Here is this week’s news of grants or gifts to historically Black colleges and universities or for programs of particular interest to African Americans in higher education.
Jackson State University, the historically Black educational institution in Mississippi, received a $420,000 grant from the CDC Foundation to develop a marketing campaign to reduce and prevent the disproportionate COVID-19 transmissions among African Americans ages 18 to 29 in Hinds, Madison, and Rankin counties. These three counties have experienced the highest rate of transmissions in Mississippi.
The College of Business at historically Black
Delaware State University received a $500,000 New Castle County Innovative Grant to create a web-based COVID Recovery Lab to help businesses in Delaware’s northernmost region recover from the pandemic. Michael Casson, dean of the College of Business, is the principal investigator of the grant. ....

Winston Salem State University , North Carolina , United States , Delaware State University , Drexel University , Michael Casson , David Dornsife , Dana Dornsife , National Institute Of Arthritis , University Of Southern California , Researchers At Washington University School Of Medicine , Jackson State University , National Institute Of Food , Rehabilitation Service Administration , Mental Health Counseling Virtual Training Initiative , School Of Public Health , Tennessee State University In Nashville , Lazarex Cancer Foundation , Herrick Corporation , Recovery Lab , College Of Business , Us Department Of Education , African American , State University , Black Delaware State University , Castle County Innovative Grant ,