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Psychedelics Open a New Window on the Mechanisms of Perception - Issue 102: Hidden Truths

Psychedelics Open a New Window on the Mechanisms of Perception - Issue 102: Hidden Truths
nautil.us - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nautil.us Daily Mail and Mail on Sunday newspapers.

United States , United Kingdom , City Of , East Sussex , Karl Friston , Juliet Griffin , Gilles Laurent , Paul Fletcher , Rajesh Rao , Andrea Alamia , Adithya Rajagopalan , G Stackman Jr , Robin Carhart Harris , Katrin Preller , Dana Ballard , University College London , University Hospital For Psychiatry Zurich , Centre De Recherche Cerveau Et Cognition , University Of Cambridge , University Of Texas At Austin , United Kingdom University Of Sussex , University Of Washington , Proceedings Of The National Academy Sciences , Imperial College London , South America , University College ,

Vitamin D deficiency exacerbates UV/endorphin and opioid addiction

The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia and reward responses triggered by ultraviolet (UV) radiation are repressed by VitD signaling, suggesting that a feedback loop exists whereby VitD deficiency produces increased UV/endorphin-seeking behavior until VitD levels are restored by cutaneous VitD synthesis. This feedback may carry the evolutionary advantage of maximizing VitD synthesis. However, unlike UV exposure, exogenous opioid use is no ....

United States , Santa Clara , Allen Brian Atlas , National Health , Sheldong Adelson Medical Research Foundation , John Wayne Cancer Institute Sequencing Center , Rosztoczy Foundation Scholarship Program , National Survey On Drug , Laboratories Inc , Soltego Inc , Research Diets Inc , Nutrition Examination , Committee At Massachusetts , National Survey , Drug Use , Nutrition Examination Survey , Massachusetts General Hospital , Some Vitd Deficient , Dietary Vitd , Rescuing Vitd , New Brunswick , Harlan Bioproducts , Institutional Animal Care , Use Committee , Massachusetts General , Inhibitory Units ,

Brain Maps May Reveal the Origins and Paths of Neurological Dysfunction

Brain Maps May Reveal the Origins and Paths of Neurological Dysfunction
Brain Maps May Reveal the Origins and Paths of Neurological Dysfunction
The Allen Institute’s Human Brain Atlas, which maps regions of the brain by gene expression, helped orient University of Cambridge researchers during an investigation of the structural changes that occur in the brains of adolescents. The researchers found that the brain regions that exhibited the greatest structural changes, as determined by magnetic resonance imaging, were correlated with the expression of schizophrenia-related genes.
Brain Maps May Reveal the Origins and Paths of Neurological Dysfunction
By combining the dynamism of functional neuroimaging and the resolution of molecular profiling, new technologies may bring obscure neurological mechanisms to light ....

United States , United Kingdom , Richarda Stein , Alanp Jasanoff , Edwardt Bullmore , Nan Li , University Of California , University Of Cambridge , Allen Institute , Proceedings Of The National Academy Sciences , Massachusetts Institute Of Technology , Allen Institute For Brain Science , Human Brain , Brain Science , Allen Human Brain Atlas , National Academy , Brain Organizes Semantic , Massachusetts Institute , Dopamine Response , Current Opinion , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , ரிச்சர்டா ஸ்டீன் , நான் லி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் ,

Development of personalised models of cognitive decline

Development of personalised models of cognitive decline
Appeared in BioNews 1096
A new model able to predict cognitive decline in Alzheimer s disease could help to develop personalised treatments.
With an aim to identify therapeutic targets, researchers at McGill University, Canada, combined results from brain scans with gene activity data. This allowed them to explore the relationship between changes in gene expression and physical changes in the brain across normal brain ageing and cognitive decline associated with Alzheimer s disease.
We wanted to combine whole-brain gene activity measurements with clinical scan data in a comprehensive and personalised model, which we then validated in healthy ageing and Alzheimer s disease said lead author Quadri Adewale. ....

Quadri Adewale , Yasser Iturria Medina , Mcgill University , Allen Human Brain Atlas , மகில் பல்கலைக்கழகம் , ஆலன் மனிதன் மூளை அட்லஸ் ,

Scientists map gene changes underlying brain and cognitive decline in aging

Scientists map gene changes underlying brain and cognitive decline in aging
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Quadri Adewale , Yasser Iturria Medina , Emily Packer , Alzheimer Disease Neuroimaging Initiative , Alice Wallenberg Foundation , Department Of Neurology , Mcgill University , Max Planck Society , Howard Hughes Medical Institute , Disease Neuroimaging Initiative , Allen Human Brain Atlas , Assistant Professor , Media Relations Manager , எமிலி ப்யாகர் , முதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி , ஆலிஸ் வாலன்பெர்க் அடித்தளம் , துறை ஆஃப் நரம்பியல் , மகில் பல்கலைக்கழகம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , நோய் நியூரோஇமேஜிங் முயற்சி , ஆலன் மனிதன் மூளை அட்லஸ் , உதவியாளர் ப்ரொஃபெஸர் , மீடியா உறவுகள் மேலாளர் ,