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Izzy Jayasinghe Harnesses Cutting-Edge Microscopy to Image Cells

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Asked what initially drew her to science, Izzy Jayasinghe has a modest answer. “I wasn’t very good at very many other things in school,” she says. “And I had, I guess, a general curiosity.” While in high school in New Zealand, Jayasinghe built a viscoelastic damper, a type of shock absorber used in cars and in buildings in earthquake-prone areas, and tested how various design parameters affected its performance.
The project won an award at a science fair for the city of Auckland, with a prize of a small scholarship to the University of Auckland, where she studied biomedicine beginning in 2003. During her senior year, Jayasinghe worked in the lab of biophysicist Christian Soeller, using a confocal microscope to examine the positions of proteins known as sodium-calcium exchangers in heart cells. Previous research had produced conflicting results on whether these exchangers colocalized with another type of protein known as ryanodine recep ....

New Zealand , United Kingdom , Izzy Jayasinghe , Mike Williamson , Christian Soeller , Alice Pyne , Sheffield Department Of Molecular Biology , University Of Queensland , University Of Leeds , University Of Exeter , University Of Auckland , University Of Sheffield , Molecular Biology , புதியது ஜீலாந்து , ஒன்றுபட்டது கிஂக்டம் , இஸீ ஜெயசிங்க , மைக் வில்லியம்சன் , ஆலிஸ் பைன் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , பல்கலைக்கழகம் ஆஃப் லீட்ஸ் , பல்கலைக்கழகம் ஆஃப் எக்ஸெடர் , பல்கலைக்கழகம் ஆஃப் ஆக்லாந்து , பல்கலைக்கழகம் ஆஃப் ஷெஃபீல்ட் , மூலக்கூறு உயிரியல் ,

Scientists Observe DNA 'Dancing' for the First Time Ever

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A team of researchers in the U.K. has announced the creation of a new dance video. And no, it’s not another enthralling TikTok clip. It is, in fact, a simulation of how a DNA loop “dances” as a stressing force is applied to it. And the dance is not only rhythmic, but also a potential way to gain key insights into how DNA interacts with other molecules.
Gizmodoreported on the observation, which stands as the first time researchers have seen DNA or deoxyribonucleic acid, a molecule consisting of two polynucleotide chains that coil around each other to form a double helix dance under pressure. (Yes, you should say that like David Bowie in your head.) ....

David Bowie , Alice Pyne , Nature Communications , University Of Leeds , University Of Sheffield , டேவிட் போவி , ஆலிஸ் பைன் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் லீட்ஸ் , பல்கலைக்கழகம் ஆஃப் ஷெஃபீல்ட் ,

Visualisation of 'dancing DNA'

Videos showing for the first time how small circles of DNA adopt dance-like movements inside a cell have been developed by researchers in. ....

Baylor College Of Medicine , United States , Lynn Zechiedrich , Sarah Harris , Massa Shoura , Alice Pyne , Nature Communications , School Of Physics , University Of Leeds , Stanford University , University Of Sheffield , Soft Matter , Baylor College , Houston Texas , Associate Professor , Professor Zechiedrich , Early Detection , Gene Therapy , பேலர் கல்லூரி ஆஃப் மருந்து , ஒன்றுபட்டது மாநிலங்களில் , சாரா ஹாரிஸ் , ஆலிஸ் பைன் , இயற்கை தகவல்தொடர்புகள் , பள்ளி ஆஃப் இயற்பியல் , பல்கலைக்கழகம் ஆஃப் லீட்ஸ் , ஸ்டான்போர்ட் பல்கலைக்கழகம் ,

Intriguing new twist to unfolding story of DNA

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Intriguing new twist to unfolding story of DNA
Scientists have developed ground-breaking techniques for visualising the stresses and strains placed on tiny twisted DNA circles.
Using advanced atomic force microscope technology and a supercomputer, the research team from the Universities of Leeds, Sheffield, York and the John Innes Centre revealed that twisted DNA can develop kinks and creases that help to package it into compact shapes.
Getting a DNA molecule into a cell involves a process of folding called supercoiling, where the DNA is twisted and looped.
The researchers believe their technique for visualising how DNA can compact so tightly will accelerate the development of new forms of gene therapy where diseases can be prevented or cured by because these very small circles of DNA can squeeze into cells more easily. ....

United States , Baylor College Of Medicine , Tony Maxwell , Lynn Zechiedrich , Sarah Harris , Massa Shoura , Alice Pyne , Nature Communications , School Of Physics , John Innes Centre , University Of Sheffield , University Of Leeds , Stanford University , Soft Matter , Baylor College , Houston Texas , Associate Professor , Professor Zechiedrich , Molecular Biology , Early Detection , Cell Nucleus , ஒன்றுபட்டது மாநிலங்களில் , பேலர் கல்லூரி ஆஃப் மருந்து , டோனி மேக்ஸ்வெல் , சாரா ஹாரிஸ் , ஆலிஸ் பைன் ,

Scientists capture the highest resolution images of a single MOLECULE of DNA

Researchers from Sheffield, Leeds and York universities combined advanced atomic microscopy with supercomputer simulations to create videos of the molecules. ....

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