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Coloring tumors reveals their bad influence


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IMAGE: Confocal micrographs of mouse small intestine with the Red2Onco technology. With Red2Onco, the oncogenic mutant clones (Red clones), and normal or wild-type clones (Yellow or Cyan clones) can be labeled.
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Credit: ©Yum/IMBA
Studies on cancer are limited by the threshold at which cellular transformations become clinically detectable. However, the very initial phase on the way to malignancy is histologically invisible, as the process originates from one single cell. In this early phase, a so-called seeding cell acquires an initial pro-cancerous mutation, also known as the first oncogenic hit , while being completely surrounded by normal tissue. To overcome the detection barrier, a team of researchers around IMBA group leader Bon-Kyoung Koo and University of Cambridge group leader Professor Benjamin D. Simons developed a laboratory system to dissect the pre-cancerous steps that remained under the radar up until present. ....

United Kingdom , Benjamin Simons , Bon Kyoung Koo , Benjamind Simons , Seungmin Han , University Of Cambridge , Austrian Federal Ministry Of Science , Gurdon Institute , Institute Of Molecular Biotechnology , Austrian Academy Of Sciences , Professor Benjamin , Min Kyu Yum , Bone Morphogenic Protein , Min Kyu , Molecular Biotechnology , Vienna Biocenter , Austrian Academy , Austrian Federal Ministry , Biomedical Environmental Chemical Engineering , Cell Biology , Developmental Reproductive Biology , Molecular Biology , ஒன்றுபட்டது கிஂக்டம் , பெஞ்சமின் சிமன்கள் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , ஆஸ்திரேலிய கூட்டாட்சியின் அமைச்சகம் ஆஃப் அறிவியல் ,

Harnessing next generation sequencing to detect SARS-CoV-2


Credit: Peter Duchek
Researchers at the Vienna BioCenter designed a testing protocol for SARS-CoV-2 that can process tens of thousands of samples in less than 48 hours. The method, called SARSeq, is published in the journal
Nature Communications and could be adapted to many more pathogens.
The COVID-19 pandemic has lasted more than a year and continues to impact our lives tremendously. Although some countries have launched speedy vaccination campaigns, many still await large-scale immunization schemes and effective antiviral therapies - before that happens, the world urgently needs to regain a semblance of normalcy.
One way to bring us closer to that point is massive parallel testing. Molecular tests that detect the presence of SARS-CoV-2 have become the best way to isolate positive cases and contain the spread of the virus. Several methods have come forward, some that detect viral proteins from nasopharyngeal swabs (such as antigen tests), and some that detect th ....

Ramesh Yelagandula , Luisa Cochella , Ulrich Elling , Ramesh Yelangandula , Nature Communications , Austrian Federal Ministry Of Science , Research Institute Of Molecular Pathology , Boehringer Ingelheim , Institute Of Molecular Biotechnology , Austrian Academy Of Sciences , Vienna Biocenter , Molecular Biotechnology , Austrian Academy , Research Institute , Molecular Pathology , Alexander Stark , Saliva Analysis , Next Generation Sequencing , Austrian Federal Ministry , இயற்கை தகவல்தொடர்புகள் , ஆஸ்திரேலிய கூட்டாட்சியின் அமைச்சகம் ஆஃப் அறிவியல் , ஆராய்ச்சி நிறுவனம் ஆஃப் மூலக்கூறு நோயியல் , போஹெரிங்கர் இஂகல்‌ஹைம் , நிறுவனம் ஆஃப் மூலக்கூறு உயிரி தொழில்நுட்பவியல் , ஆஸ்திரேலிய கலைக்கழகம் ஆஃப் அறிவியல் , மூலக்கூறு உயிரி தொழில்நுட்பவியல் ,