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 E-Mail IMAGE: Confocal micrographs of mouse small intestine with the Red2Onco technology. With Red2Onco, the oncogenic mutant clones (Red clones), and normal or wild-type clones (Yellow or Cyan clones) can be labeled... view more  Credit: ©Yum/IMBA Studies on cancer are limited by the threshold at which cellular transformations become clinically detectable. However, the very initial phase on the way to malignancy is histologically invisible, as the process originates from one single cell. In this early phase, a so-called "seeding cell" acquires an initial pro-cancerous mutation, a...

Do our brains age faster than the rest of our bodies? April 21, 2021USC If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a new study published in  Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly. “There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engi...

Credit: Albina Ibrayeva/Bonaguidi Lab In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly. "There is chronological aging, and there is biological aging, and they are not the same thing," said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. "We're interested in the biological aging of neural stem cells, which are particularly vulnerable to t...