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Do our brains age faster than the rest of our bodies? April 21, 2021USC If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells the stem cells of the nervous system age rapidly. “There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer’s disease, epilepsy and brain injury.” ....
Credit: Albina Ibrayeva/Bonaguidi Lab In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly. There is chronological aging, and there is biological aging, and they are not the same thing, said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. We re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer s disease, epilepsy and brain injury. ....