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Flagship's Repertoire bags $189M to go after immune targets

John Cox, Repertoire s CEO (left) and Douglas Cole, M.D., Repertoire s chairman (Repertoire)
Repertoire Immune Medicines has raised $189 million to advance anti-cancer T-cell therapies through the clinic while expanding its immune response drug discovery platform.
Flagship Pioneering created Repertoire by combining two of its portfolio companies, Cogen Immune Medicines and Torque Therapeutics. The VC shop oversaw the merger to bring together the immune decoding and immuno-oncology platforms that underpinned Cogen and Torque, respectively, and put former Bioverativ CEO John Cox in charge of the combined company.
Now, Repertoire has raised a series B round to support the next stage of its development. Repertoire framed the financing primarily in the context of what it will mean for the DECODE technologies it has developed to characterize the immune synapse. ....

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Webinars on covid-19, SPME, in vitro diagnostics and pharma

In Vitro Diagnostic Regulation (IVDR)
Join three leaders in the field of
in vitro diagnostics, as they examine the new responsibilities of economic operators, whether your product is an IVD according to IVDR classification, and explore research use only versus general lab use in relation to IVDs.
Wednesday, April 7 at 15:00 BST / 16:00 CEST / 10:00 EDT / 07:00 PDT
IMMUNOLOGY: Ask the experts: Addressing challenges in a new era of flow cytometry
Key opinion leaders in the areas of immunology and flow cytometry will provide insights and best practices to support researcher on their path to experimental success.
Tuesday, April 13, at 16:00 BST / 17:00 CEST / 11:00 EDT / 08:00 PDT ....

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GeoVax to Participate in Benzinga Biotech Small Cap Conference

GeoVax to Participate in Benzinga Biotech Small Cap Conference
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GSK, German Merck's $4.2B bintrafusp alfa drug flops again, but companies squint to see glimmers of hope

Mar 16, 2021 4:34am
GlaxoSmithKline and Merck KGaA’s bintrafusp alfa failed in second-line patients with locally advanced or metastatic biliary tract cancer. (GSK)
Two months after GlaxoSmithKline and Merck KGaA’s oncology asset bintrafusp alfa failed to beat out King Keytruda in certain lung cancers, it has followed up with another disappointment.
The bifunctional fusion protein immunotherapy, which is the center of the $4.2 billion deal GSK penned with Merck in 2019, flopped a midstage test on its own treating 159 second-line patients with locally advanced or metastatic biliary tract cancer (BTC).
An independent review showed it had an objective response rate (ORR) of just 10.1% , with efficacy hitting below a predefined threshold that would have let it file the drug in that setting. ....

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8 top webinars in life science, clinical diagnostics, pharma

Discover how the Incucyte
® Live-Cell Analysis offers walkaway monitoring of tumor cell lysis using fluorescent labels of cytotoxicity. In this webinar, Cellero s Chief Science and Innovation Officer, Dr. Anne Lodge, will present data using tumor antigen-specific T cells from Cellero and widely available tumor cell lines to demonstrate specific lysis of tumor cells. Important technical factors will be discussed.
Tuesday, March 16, at 16:00 GMT / 17:00 CET/ 11:00 EST / 08:00 PST
TROPONIN: Time - the most precious resource: Part two of the high-sensitivity troponin webinar series
Dr. Frank Peacock, professor, associate chair and research director for emergency medicine at Baylor College of Medicine, will review the utilization of troponin assays in the assessment of acute coronary syndrome (ACS). This will highlight the differences between contemporary troponin vs. high-sensitive troponin and the role each play in the assessment of patients presenting with is ....

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