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A sturdier spike protein explains the faster spread of coronavirus variants


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IMAGE: This model shows the structure of the spike protein in its closed configuration, in its original D614 form (left) and its mutant form (G614). In the mutant spike protein, the.
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Credit: Bing Chen, PhD, Boston Children s Hospital
BOSTON - March 16, 2021 - The fast-spreading UK, South Africa, and Brazil coronavirus variants are raising both concerns and questions about whether COVID-19 vaccines will protect against them. New work led by Bing Chen, PhD, at Boston Children s Hospital analyzed how the structure of the coronavirus spike proteins changes with the D614G mutation carried by all three variants and showed why these variants are able to spread more quickly. The team reports its findings in ....

United States , South Africa , United Kingdom , Jun Zhang , Hanqin Peng , Piotr Sliz , Haisun Zhu , Yongfei Cai , Bing Chen , Alec Woosley , Richard Walsh Jr , Tianshu Xiao , Jianming Lu , Structural Biology Harvard Medical School , National Institutes Of Health , Harvard Center , Boston Children Division Of Molecular Medicine , Codex Biosolutions Inc , Boston Children , Nature Structural , Molecular Biology , Molecular Medicine , Sophia Rits Volloch , Codex Biosolutions , Sarah Sterling , Richard Walsh ,

Wren Therapeutics Announces Financing of 12.4 Million (c. $17.0 Million)


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Wren Therapeutics Ltd., (“Wren”), a biopharmaceutical company pioneering a unique network kinetics approach to drug discovery for protein misfolding diseases, today announced the closing of a £12.4 million (c. $17.0 million) financing.
This financing brings the total capital raised to date to approximately £33 million (c. $45 million). The financing was led by existing shareholder The Baupost Group, with participation from existing investors including LifeForce Capital and new investors including Schooner Capital and Industry Ventures.
Dr. Samuel Cohen, Chief Executive Officer of Wren, commented: “This support from both our existing as well as our new shareholders will accelerate the advancement of our two lead small molecule programs towards the clinic for the potential treatment of Alzheimer’s disease and various synucleinopathies including Parkinson’s disease.” ....

United States , Rowen Hughes , Samuel Cohen , Emer Reynolds , Lund University Sweden , Milken Institute , National Cancer Institute , Dartmouth College , Board Of Bausch Health , Baupost Group , Board Of Directors At Radius Health , Fidelity Investments Company , Celularity Inc , University Of Cambridge United Kingdom , Georgetown University , Radius Health , Clinical Development , Bausch Health , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Drug Administration , Bipartisan Policy Center , Samaritan Health Initiatives Inc , Eisai Co Ltd , Head Of Corporate Development At Intarcia Therapeutics , Wren Therapeutics Ltd ,

Wren Therapeutics Announces Financing of £12.4 Million (c. $17.0 Million)


Press release content from Business Wire. The AP news staff was not involved in its creation.
Wren Therapeutics Announces Financing of £12.4 Million (c. $17.0 Million)
January 25, 2021 GMT
CAMBRIDGE, United Kingdom (BUSINESS WIRE) Jan 25, 2021
Wren Therapeutics Ltd., (“Wren”), a biopharmaceutical company pioneering a unique network kinetics approach to drug discovery for protein misfolding diseases, today announced the closing of a £12.4 million (c. $17.0 million) financing.
This financing brings the total capital raised to date to approximately £33 million (c. $45 million). The financing was led by existing shareholder The Baupost Group, with participation from existing investors including LifeForce Capital and new investors including Schooner Capital and Industry Ventures. ....

United Kingdom , United States , Rowen Hughes , Samuel Cohen , Emer Reynolds , Lund University Sweden , Milken Institute , National Cancer Institute , Dartmouth College , Board Of Bausch Health , Baupost Group , Board Of Directors At Radius Health , Fidelity Investments Company , Celularity Inc , University Of Cambridge United Kingdom , Georgetown University , Radius Health , Clinical Development , Bausch Health , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Drug Administration , Bipartisan Policy Center , Samaritan Health Initiatives Inc , Eisai Co Ltd , Head Of Corporate Development At Intarcia Therapeutics ,