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DOAC After Heart Valve Procedure?

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Direct oral anticoagulants (DOACs) are getting used off-label with prosthetic heart valves, even mechanical valves in some cases, a national registry showed.
At least some valve patients were discharged with a DOAC prescription at 78.6% 0f the 1,092 hospitals and by 59.6% of the 2,731 physicians participating in the Society of Thoracic Surgeons Adult Cardiac Surgery Database from July 2014 through June 2017.
For mechanical heart valve recipients, the rate was 1.1% with aortic valve replacement and 1.04% with mitral valve replacement, without significant change over time for either, Ankur Kalra, MD, of the Cleveland Clinic, and colleagues reported in
I am really very surprised that DOACs are being used in mechanical heart valves, commented Deepak Bhatt, MD, MPH, of Brigham and Women s Hospital Heart & Vascular Center and Harvard Medical School in Boston, who was not involved with the study. ....

United States , Ankur Kalra , Deepak Bhatt , Harvard Medical School , Women Hospital Heart Vascular Center , Thoracic Surgeons Adult Cardiac Surgery Database , Cleveland Clinic , Hospital Heart , Vascular Center , Heart Valve Disorder , Blood Coagulation Disorder , Occlusion Of Artery , ஒன்றுபட்டது மாநிலங்களில் , அன்குர் கல்ரா , தீபக் பட் , ஹார்வர்ட் மருத்துவ பள்ளி , பெண்கள் மருத்துவமனை இதயம் வாஸ்குலர் மையம் , கிளீவ்லேண்ட் சிகிச்சையகம் , மருத்துவமனை இதயம் , வாஸ்குலர் மையம் , இதயம் அடைப்பான் கோளாறு , இரத்தம் உறைதல் கோளாறு ,

Femtech startup OCON Healthcare announces last patient in phase IIa clinical study, evaluating its intrauterine drug delivery platform IUB SEAD, a non-invasive treatment for abnormal uterine bleeding (AUB)

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The trial assesses the safety and efficacy of the IUB SEAD, a disruptive treatment for AUB. In this study, 50% of the participating patients have reached the End of the Study point, demonstrating a significant reduction in bleeding, avoiding the need to undergo invasive uterine ablation procedures or even a hysterectomy
MODIIN, Israel, March 4, 2021 /PRNewswire/
OCON Healthcare, a women s health company which develops, manufactures and commercializes an innovative 3D intrauterine drug delivery technology based on its patented IUB
TM (Intra Uterine Ball) platform, today announced it had completed enrollment of its Phase IIa clinical study evaluating its intrauterine drug delivery platform IUB SEAD,a non-invasive treatment for abnormal uterine bleeding (AUB). ....

Israel General , Ravit Levrann , Kostenloser Wertpapierhandel , Sergio Haimovich , Intra Uterine Ball , Abnormal Uterine Bleeding , Chief Medical Officer , Health Care , இஸ்ரேல் ஜநரல் , இன்ட்ரா கருப்பை பந்து , இயல்பு கடந்த கருப்பை இரத்தப்போக்கு , தலைமை மருத்துவ அதிகாரி , ஆரோக்கியம் பராமரிப்பு , இயல்பு கடந்த ,

Coronavirus deranges the immune system in complex and deadly ways

There's a reason soldiers go through basic training before heading into combat: Without careful instruction, green recruits armed with powerful weapons could be as dangerous to one another as to the enemy. ....

United States , City Of , United Kingdom , Nina Luning Prak , James Heath , Judith James , John Wherry , Emily Henderson , Nathan Peiffer Smadja , Luning Prak , Angela Rasmussen , Centers For Disease , Rockefeller University Casanova , Yale School Of Medicine , Georgetown Center , National Institutes Of Health , Stanford University School Of Medicine , Harvard Medical School , Global Health Science , Oklahoma Medical Research Foundation , Imperial College London , Toronto Centre For Liver Disease , Seattle Institute For Systems Biology , Rockefeller University Jean Laurent Casanova , Penn Medicine Immune Health Institute , Rockefeller University ,

New Narcolepsy Tx Under Review; Schizophrenia Drug Flops in Trial

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The FDA accepted Avadel Pharmaceuticals marketing application for a daily sodium oxybate treatment, FT218, for excessive daytime sleepiness and cataplexy in adults with narcolepsy, the company said.
England saw a nearly 4% uptick in new antidepressant prescriptions during the COVID-19 pandemic. (
The Lancet Psychiatry)
Diversity, equity, and inclusion leaders in academic medicine often don t have the resources they need to implement change, according to a new guideline for success in the
American Journal of Psychiatry.
Luvadaxistat, an investigational treatment for negative symptoms of schizophrenia, failed in a phase II trial. (
BioPharmaDive)
But in other trial news, an accelerated 5-day course of intermittent theta-burst stimulation with Nexstim s Navigated Brain Therapy device succeeded in reducing symptoms of severe depression, the maker announced. ....

New York , United States , Journal Of Health Care For The Poor , American Academy Of Neurology , Avadel Pharmaceutical , Lancet Psychiatry , American Journal , Navigated Brain Therapy , American Academy , Health Care , New York City , Blood Coagulation Disorder , Anxiety Attack , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , இதழ் ஆஃப் ஆரோக்கியம் பராமரிப்பு க்கு தி புவர் , அமெரிக்கன் கலைக்கழகம் ஆஃப் நரம்பியல் , அமெரிக்கன் இதழ் , அமெரிக்கன் கலைக்கழகம் , ஆரோக்கியம் பராமரிப்பு , புதியது யார்க் நகரம் , இரத்தம் உறைதல் கோளாறு , பதட்டம் தாக்குதல் ,

Common Antidepressants May not Raise the Risk of Stroke

Common Antidepressants May not Raise the Risk of Stroke
by Angela Mohan on
March 1, 2021 at 12:20 PM
SSRIS may not raise the risk of intracerebral hemorrhage among patients with depression, as per the study that will be presented at the American Academy of Neurology s 73rd Annual Meeting being held virtually April 17 to 22, 2021.
An intracerebral hemorrhage is when a blood vessel bursts in the brain sending blood into the surrounding tissue. The most common causes are high blood pressure and head trauma, but some studies have also suggested that SSRIs may increase a person s risk of this type of bleeding stroke.
Selective serotonin reuptake inhibitors work by preventing reabsorption of the chemical serotonin, which regulates mood, into the cells, making more of it available in the brain, said study author Mithilesh Siddu, M.D., of the University of Miami in Florida and member of the American Academy of Neurology. ....

United States , University Of Miami , Mithilesh Siddu , American Academy Of Neurology , American Academy , Annual Meeting , Palsydiet Lifestyle , Mood Regulation , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் மியாமி , மிதிலேஷ் சிட்டு , அமெரிக்கன் கலைக்கழகம் ஆஃப் நரம்பியல் , அமெரிக்கன் கலைக்கழகம் , ஆண்டு சந்தித்தல் , மனநிலை ஒழுங்குமுறை ,