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 E-Mail IMAGE: The global brain signal in Alzheimer s disease patients is associated with weaker cerebrospinal fluid flow as compared with healthy controls view more  Credit: Feng Han and Xiao Liu @ The Pennsylvania State University Evidence of sleep-dependent low-frequency (PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients. The development of Alzheimer s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cerebrospinal fluid f

University of southern californiaUnited statesSouth koreaXiao liuEli lillyMichael weinerFoundation for the national institutes of healthDepartment of defenseNeurorx researchMeso scale diagnosticsNational institute of biomedical imagingMerck co incPfizer incLaboratory for neuro imagingYork universityRoche ltd