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Chutes & Ladders—AltruBio snags new CMO with resume at Sublimity, Ardea, Amgen and Abbott

Chutes & Ladders—AltruBio snags new CMO with resume at Sublimity, Ardea, Amgen and Abbott
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Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer's disease


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IMAGE: The global brain signal in Alzheimer s disease patients is associated with weaker cerebrospinal fluid flow as compared with healthy controls
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Credit: Feng Han and Xiao Liu @ The Pennsylvania State University
Evidence of sleep-dependent low-frequency (PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.
The development of Alzheimer s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cer ....

University Of Southern California , United States , South Korea , Xiao Liu , Eli Lilly , Michael Weiner , Foundation For The National Institutes Of Health , Department Of Defense , Neurorx Research , Meso Scale Diagnostics , National Institute Of Biomedical Imaging , Merck Co Inc , Pfizer Inc , Laboratory For Neuro Imaging , York University , Roche Ltd , Elan Pharmaceuticals Inc , Transition Therapeutics , Alzheimer Disease Neuroimaging Initiative , Eisai Inc , Pennsylvania State University , Boston University , Canadian Institutes Of Health Research , National Institutes Of Health Grant , Johnson Pharmaceutical Research Development , Northern California Institute For Research ,