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U-M RNA scientists identify many genes involved in neuron development


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IMAGE: Neurons in the fruit fly brain are made by passing through various differentiation states, and are segregated into unique subtypes based on the age and cell division number of their.
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Credit: Nigel Michki
Neurons result from a highly complex and unique series of cell divisions. For example, in fruit flies, the process starts with stem cells that divide into mother cells (progenitor cells), that then divide into precursor cells that eventually become neurons.
A team of the University of Michigan (U-M), spearheaded by Nigel Michki, a graduate student, and Assistant Professor Dawen Cai in the departments of Biophysics (LS&A) and Cell and Developmental Biology at the Medical School, identified many genes that are important in fruit flies neuron development, and that had never been described before in that context. ....

Life Sciences Institute , United States , Nigel Michki , Dawen Cai , Cheng Yu Lee , Cai Lab , University Of Michigan Medical School , Yum Center , Um Life Sciences Institute , Department Of Cell , University Of Michigan , Assistant Professor Dawen Cai , Developmental Biology , Medical School , Cell Reports , Michigan Medical School , Um Life Sciences , Flow Cytometry Core , Advanced Genomics , Stem Cell Biology , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் மருத்துவ பள்ளி , உம் மையம் , உம் வாழ்க்கை அறிவியல் நிறுவனம் , துறை ஆஃப் செல் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் ,

New research reveals how one antibody blocks dangerous effects of dengue virus infection, offering a potential path to prevention


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New research reveals how one antibody blocks dangerous effects of dengue virus infection, offering a potential path to prevention
Researchers have revealed how one antibody (in green) is able to neutralize a protein that is central to the dengue virus’s ability to cause disease, by blocking the protein’s ability to interact with host cells. Image credit: Rajani Arora, U-M Life Sciences Institute
A team of researchers has discovered an antibody that blocks the ability of the dengue virus to cause disease in mice. The findings open the potential for developing effective treatments and designing a vaccine for dengue and similar diseases. ....

United States , Life Sciences Institute , Marcusp Wong , Dustinr Glasner , Michaelj Mina , Janet Smith , Nicholasj Bockhaus , Davidl Akey , Jamier Konwerski , David Akey , Jeffrey Li , Scottb Biering , Chunling Wang , Rajani Arora , Scott Biering , W Clay Brown , Janetl Smith , P Robert Beatty , Francielle Tramontini Gomes , Stephenj Elledge , Diegoa Espinosa , Sophief Blanc , Evany Juan , Henry Puerta Guardo , Keva Harris , University Of California ,