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Monoclonal antibodies can be an effective tool in the global fight against malaria


Monoclonal antibodies can be an effective tool in the global fight against malaria
Scientists at Walter Reed Army Institute of Research, in collaboration the Duke University, have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria.
The study, led by Dr. Sheetij Dutta, chief of the Structural Vaccinology Laboratory at WRAIR, showed that mAbs such as CIS43 was most effective in a culture-based assay that measured a malaria parasite s ability to infect a human liver cell, while another mAb 317 showed the best activity in a mouse infection model.
Dutta added, difference in assay outcomes for mAbs could reflect distinct sites on the circumsporozoite protein, that can be exploited for developing improved vaccines. The study results were published today in ....

Sheetij Dutta , Jason Regules , Emily Henderson , Walter Reed Army Institute Of Research , Malaria Biologics Branch , Duke University , Structural Vaccinology Laboratory , Army Col , Walter Reed Army Institute , Nature Scientific , Biologics Branch , எமிலி ஹென்டர்சன் , வால்டர் நாணல் இராணுவம் நிறுவனம் ஆஃப் ஆராய்ச்சி , மலேரியா உயிரியல் கிளை , டியூக் பல்கலைக்கழகம் , கட்டமைப்பு தடுப்பூசி ஆய்வகம் , இராணுவம் கால் , வால்டர் நாணல் இராணுவம் நிறுவனம் , இயற்கை அறிவியல் , உயிரியல் கிளை ,