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Coupled brain activity, cerebrospinal fluid flow could indicate Alzheimer's risk


Penn State researchers have found that the signal of global brain activity is coupled to movement of cerebral spinal fluid in humans. It appears that the coupled movement cleans out the brain’s toxins as a person sleeps. The weaker the coupled movement, the higher the risk the person could develop Alzheimer’s disease. The signal can viewed via non-invasive brain imaging and could serve as a clinical marker to help in diagnosis.
Penn State College of Engineering
First described in 2012, the glymphatic system acts as a waste management system, washing out the proteins and other buildup that can hinder brain activity. The critical component of the system is the cerebrospinal fluid flow, according to Liu, which his research suggests is activated by the global BOLD signal activation. In sleep, the glymphatic system can speed up its cleaning processes significantly.  ....

United States , Feng Han , Yameng Gu , Jing Chen , Orfeum Buxton , Aaron Belkin Rosen , Xiao Liu , College Of The Liberal Arts , Human Development , Institute Of Computational , Penn State College Of Engineering , College Of Health , Alzheimer Disease Neuroimaging Initiative , Population Research Institute , Department Of Defense , National Institutes Of Health , Department Of Biomedical Engineering , White House Brain Research , Society Collaboratory At Penn , Elizabeth Fenton Susman Professor Of Biobehavioral Health , Data Sciences , Penn State , Biomedical Engineering , State College , Elizabeth Fenton Susman Professor , Biobehavioral Health ,

Maternal stress during pregnancy may shorten lifespans of male lizard offspring


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IMAGE: Mother fence lizards that experience stress during pregnancy give birth to male offspring with shortened telomeres, which is associated with shortened life spans, according to new research.
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Credit: Tracy Langkilde, Penn State
UNIVERSITY PARK, Pa. Mother fence lizards that experience stress during pregnancy give birth to male offspring with shortened telomeres, or bits of non-coding DNA that cap the ends of chromosomes, according to a Penn State-led study. Shorter telomeres are associated with decreased lifespan in humans; therefore, the team s findings may have implications for human longevity.
Human men have shorter telomeres than women, which may partly explain why they have shorter lifespans of about seven years, said Tracy Langkilde, professor and Verne M. Willaman dean of the Eberly College of Science. Our study shows that stress experienced by mothers during gestation could further shorten the telomeres, and theref ....

United States , Dustin Owen , Vernem Willaman , Tracy Langkilde , David Ensminger , University Of Massachusetts Dartmouth , Eberly College Of Science , Department Of Biobehavioral Health , Biomarker Core Lab , National Science Foundation , San Jose State University , Penn State Led , Eberly College , Comparative Biochemistry , Physiology Part , Biobehavioral Health , Penn State , Michael Sheriff , ஒன்றுபட்டது மாநிலங்களில் , டஸ்டின் ஓவந் , டேவிட் உறுதிப்படுத்தும் , பல்கலைக்கழகம் ஆஃப் மாசசூசெட்ஸ் டார்ட்மவுத் , எபேர்லி கல்லூரி ஆஃப் அறிவியல் , துறை ஆஃப் உயிர் நடத்தை ஆரோக்கியம் , பயோமார்க் கோர் ஆய்வகம் , தேசிய அறிவியல் அடித்தளம் ,