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A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma

A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
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South Africa , Canton De Vaud , South African , Vaud Canton , Global Health Drug Discovery Institute , Swiss Federal Office Of Public Health , European Federation Of Pharmaceutical Industries Associations , Allergy Service , University Of Lausanne Unisant , Melinda Gates Foundation , Innovative Medicines Initiative , Public Health , Centre For Primary Care , Bj Bosch Utrecht University , University Of Texas , Lausanne University Hospital , Swiss National Science Foundation , Fred Hutchinson Cancer Research Center , University Of Dundee , European Union Horizon , Swiss Federal Office Of Health , National Institutes Of Health , Service Of Immunology , Foundation For Innovative New Diagnostics , Swiss Vaccine Research Institute , Primary Care ,

Phenotypes of Mild-to-Moderate Obstructive Pulmonary Disease

Purpose: Asthma and chronic obstructive pulmonary disease (COPD) are complex and heterogeneous inflammatory diseases. We sought to investigate distinct disease profiles based on clinical, cellular and molecular data from patients with mild-to-moderate obstructive pulmonary diseases.
Patients and Methods: Patients with mild-to-moderate allergic asthma (n=30) and COPD (n=30) were prospectively recruited. Clinical characteristics and induced sputum were collected. In total, 35 mediators were assessed in induced sputum. Logistic regression analysis was conducted to identify the optimal factors that were able to discriminate between asthma and COPD. Further, the data were explored using hierarchical clustering in order to discover and compare clusters of combined samples of asthma and COPD patients. Clinical parameters, cellular composition, and sputum mediators of asthma and COPD were assessed between and within obtained clusters. ....

United States , Waals Gewest , Eteläuomen Läi , Biomedica Medizinprodukte Gmb , Global Initiative For Chronic Obstructive Lung Disease , American Thoracic Society European Respiratory , University Of Warsaw , Statsoft Inc , R Foundation For Statistical Computing , Global Initiative For Asthma , Medical University , Global Initiative , Chronic Obstructive Lung , Port Washington , Ethics Committee , American Thoracic , European Respiratory Society , Elecsys Ige , Roche Diagnostics Gmbh , Bio Plex Pro , Human Cytokine , Bio Rad Laboratories , Demeditec Diagnostics Gmbh , Biomedica Medizinprodukte Gmbh , Whitneyu Test , Statistical Computing ,

Bio-Plex Pro SARS-CoV-2 multiplex serology assays

Bio-Plex Pro SARS-CoV-2 multiplex serology assays
Chamila Rupasinghe, Progressive Diagnostics LLC
Jean-François RAMEAU, Sanofi
Lynn Cunningham, Adena Health System
Donna James, Piedmont Interventional Pain Care, PA
Sudhir Sharma, New York University Abu Dhabi
Sunil Kumar Gahlaut, USV PRIVATE LTD
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The Bio-Plex Pro SARS-CoV-2 Serology Assays provide COVID-19 researchers with sensitive and specific assays to monitor the antibody immune response profile against four viral proteins. Download this flier to find out more.
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