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Early Release - Vaccine-Derived Polioviruses, Central African Republic, 2019 - Volume 27, Number 2—February 2021 - Emerging Infectious Diseases journal


Abstract
Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations ( 20) in the viral capsid protein 1–encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably 3 years) before being isolated. Environmental surveillance, which relies on a limited number of sampling sites in the Central African Republic and does not cover the whole country, failed to detect the circulation of VDPV-2s before some had induced poliomyelitis in children. ....

Central African Republic , Global Polio Laboratory Network , Central African , Appendix Figure , Oral Polio Vaccine , Polio Virus , Vaccine Derived Poliovirus , உலகளாவிய போலீயோ ஆய்வகம் வலைப்பின்னல் , பின் இணைப்பு எண்ணிக்கை , வாய்வழி போலீயோ தடுப்பூசி , போலீயோ வைரஸ் ,