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Nanotechnology Now - Press Release: Pore-like proteins designed from scratch: By creating barrel-shaped proteins that embed into lipid membranes, biochemist have expanded the bioengineering toolkit


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Home > Press > Pore-like proteins designed from scratch: By creating barrel-shaped proteins that embed into lipid membranes, biochemist have expanded the bioengineering toolkit
Abstract:
In a milestone for biomolecular design, a team of scientists has succeeded in creating new proteins that adopt one of the most complex folds known to molecular biology. These designer proteins were shown in the lab to spontaneously fold into their intended structures and embed into lipid membranes. Reported in the journal Science, this research opens the door to the construction of custom nanoscale tools for advanced filtration and DNA sequencing.
Pore-like proteins designed from scratch: By creating barrel-shaped proteins that embed into lipid membranes, biochemist have expanded the bioengineering toolkit ....

Nordrhein Westfalen , Binyong Liang , Ian Haydon , Sheena Radford , Lukas Tamm , David Baker , Leila Gray , Johns Hopkins University , Institute For Protein Design , Research Awards Scholarships Gifts Contests Honors Records , Astbury Centre For Structural Molecular Biology , Ohio State University , University Of Virginia School Medicine , University Of Bonn , University Of Washington , University Of Washington School Medicine , University Of Leeds , Degree Capital Corp , Uw Medicine Institute For Protein Design , Wave Inc , Home Press , Protein Design , Washington School , Astbury Professor , Astbury Centre , Structural Molecular Biology ,

Pore-like proteins designed from scratch


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IMAGE: Newly designed beta-barrel proteins fold spontaneously into their intended structures and embed into lipid membranes. How the proteins were created from scratch, and their future potential in the construction of.
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Credit: Ian Haydon, UW Medicine Institute for Protein Design
In a milestone for biomolecular design, a team of scientists has succeeded in creating new proteins that adopt one of the most complex folds known to molecular biology. These designer proteins were shown in the lab to spontaneously fold into their intended structures and embed into lipid membranes. Reported in the journal
Science, this research opens the door to the construction of custom nanoscale tools for advanced filtration and DNA sequencing. ....

Binyong Liang , Ian Haydon , Sheena Radford , Lukas Tamm , David Baker , Johns Hopkins University , Institute For Protein Design , Astbury Centre For Structural Molecular Biology , Ohio State University , University Of Virginia School Medicine , University Of Washington School Medicine , University Of Leeds , Uw Medicine Institute For Protein Design , Protein Design , Washington School , Astbury Professor , Astbury Centre , Structural Molecular Biology , Virginia School , Ohio State , Biomedical Environmental Chemical Engineering , Molecular Biology , Chemistry Physics Materials Sciences , Technology Engineering Computer Science , Nanotechnology Micromachines , ஈயந் ஹைடன் ,

New biosensors quickly detect coronavirus proteins and antibodies


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IMAGE: An illustration of a new biosensor binding to a targeted molecule and emitting light. The creation of the biosensor was led by the UW Medicine Institute for Protein Design.
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Credit: Ian Haydon/UW Medicine Institute for Protein Design
Scientists have created a new way to detect the proteins that make up the pandemic coronavirus, as well as antibodies against it. They designed protein-based biosensors that glow when mixed with components of the virus or specific COVID-19 antibodies. This breakthrough could enable faster and more widespread testing in the near future. The research appears in
Nature.
To diagnose coronavirus infection today, most medical laboratories rely on a technique called RT-PCR, which amplifies genetic material from the virus so that it can be seen. This technique requires specialized staff and equipment. It also consumes lab supplies that are now in high demand all over the world. Supply-chain shortfa ....

United States , Ian Haydon , David Baker , Wendy Schmidt , Institute For Protein Design , National Institutes Of Health , Nordstrom Barrier Fund , Caixa Foundation , United World Antiviral Research Network , Centers Researching Emerging Infectious Diseases , Washington Research Foundation , Lg Yonam Foundation , Uw Medicine Institute For Protein Design , Office Of Scientific Research , Howard Hughes Medical Institute , Protein Design , National Institutes , Air Force Office , Scientific Research , Audacious Project , Schmidt Futures , Open Philanthropy Project , Gree Real Estate , ஒன்றுபட்டது மாநிலங்களில் , ஈயந் ஹைடன் , டேவிட் ரொட்டி சுடுபவர் ,