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Memory biomarkers confirm aerobic exercise helps cognitive function in older adults

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IMAGE: The enhanced physical activity group underwent 26 weeks of supervised treadmill training. Blood samples for both groups were taken at baseline and after 26 weeks.
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Credit: Florida Atlantic University
Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimer s disease (AD). In aging humans, aerobic exercise training increases gray and white matter volume, enhances blood flow, and improves memory function. The ability to measure the effects of exercise on systemic biomarkers associated with risk for AD and relating them to key metabolomic alterations may further prevention, monitoring, and treatment efforts. However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. ....

United States , Soult Ukpyolsi , South Korea , Madison School , University Of Wisconsin , Palm Beach County , Ozioma Okonkwo , Denab Dubal , Julianm Gaitan , Henriette Van Praag , Daneb Cook , Matthew Stremlau , Johnd Macarthur , Florida Department Of Health Ed , Madison School Of Education , Seoul National University , National Institute On , Extendicare Foundation , Robic Exercise And Cognitive Health , Florida Atlantic University Schmidt College Of Medicine , Brain Institute , Institute For Human Health Disease Intervention , Alzheimer Association , University Of California San Francisco , Department Of Medicine , Charlese Schmidt College Of Medicine ,

Mayo researchers, collaborators identify 'instigator' gene associated with Alzheimer's disease

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Mayo researchers, collaborators identify ‘instigator’ gene associated with Alzheimer’s disease
JACKSONVILLE, Fla. – In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer’s disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the relevance of the gene to Alzheimer’s disease.
The researchers used tissue samples from 385 brains donated to the Mayo Clinic Brain Bank, which houses more than 9,000 brain tissue specimens for the study of neurodegenerative disorders. The samples were from people who were diagnosed with Alzheimer’s disease and lacked co-existing diseases found in the brain. This ensured a spotlight on Alzheimer’s disease, which enabled the team to focus on targets relevant to t ....

United States , Neill Graff Radford , Christina Moloney , Rickey Carter , Frances Strawn , Michael Deture , Ronald Petersen , Owen Ross , Yan Asmann , Minerva Carrasquillo , Tulsi Patel , Xiaojia Tang , Billie Matchett , Ranjan Duara , Melissa Murray , Xue Wang , Nilufer Taner , Zachary Quicksall , Angela Crist , Dennis Dickson , Wien Center , Nature Communications , National Institute On , Florida Department Of Health , Mayo Clinic Brain Bank , Ethel Moore Alzheimer Disease Research ,

Mayo researchers, collaborators identify 'instigator' gene associated with Alzheimer's disease

Mayo researchers, collaborators identify 'instigator' gene associated with Alzheimer's disease
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United States , Neill Graff Radford , Christina Moloney , Rickey Carter , Frances Strawn , Michael Deture , Ronald Petersen , Yan Asmann , Owen Ross , Minerva Carrasquillo , Tulsi Patel , Xiaojia Tang , Billie Matchett , Ranjan Duara , Melissa Murray , Nilufer Taner , Xue Wang , Zachary Quicksall , Dennis Dickson , Angela Crist , Wien Center , Nature Communications , National Institute On , Florida Department Of Health , Mayo Clinic Brain Bank , Ethel Moore Alzheimer Disease Research ,