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New genetic copycatchers detect efficient and precise CRISPR editing in a living organism

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IMAGE: Red fluorescent detector proteins in fruit flies reveal detection from an actual copying experiment (left) and how perfect copying would appear (right). Fluorescent cells in the left panel also lack.
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Credit: Zhiqian Li
Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques.
Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier s laboratory demonstrates that new DNA repair mechanisms could be designed to address the effects of debilitating diseases and damaged cell conditions. ....

San Diego , United States , University Of California San Diego , Sushil Devkota , Stephen Hedrick , Nimi Marcel , Zhiqian Li , Valentino Gantz , Ankush Auradkar , Nature Communications , Tata Institute For Genetics , National Institutes Of Health , Division Of Biological Sciences Professor Ethan Bier , Synbal Inc , Agragene Inc , California San Diego , Biological Sciences Professor Ethan Bier , Tata Institute , National Institutes , Frontiers Group Distinguished Investigators Award , Tata Trusts , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , ஸ்டீபன் ஹெட்ரிக் , வாலண்டினோ காண்டஜ ,

Researchers Unveil Detailed Genome of Invasive Malaria Mosquito

Researchers Unveil Detailed Genome of Invasive Malaria Mosquito
New ‘gold standard’ reference genome reveals thousands of new genes vital for targeting pathogen transmission and immunity
Adult female Anopheles stephensi mosquito.
Newswise Despite the broad notoriety of sharks, snakes, scorpions and other formidable creatures, mosquitoes remain the deadliest animal on the planet… by far. Mosquito-transmitted malaria remains the number one worldwide killer among vector-borne diseases, claiming more than 400,000 human lives in 2019.
In order to engineer advanced forms of defense against malaria transmission, including targeted CRISPR and gene drive-based strategies, scientists require intricate knowledge of the genomes of vector mosquitoes.
Mahul Chakraborty a project scientist at the University of California, Irvine, working with colleagues at the Tata Institute for Genetics and Society (TIGS) at UC San Diego and India, and the Institute of Bioinformatics ....

United States , San Diego , Luna Thanh Ngo , Anthony James , Suvratha Jayaprasad , Subhashini Srinivasan , Suresh Subramani , Arunachalam Ramaiah , Kiran Paul , Saurabh Whadgar , Bhagyashree Kaduskar , Mahul Chakraborty , Paige Halas , Adriana Adolfi , University Of California , Tata Institute For Genetics , Institute Of Bioinformatics , National Institutes Of Health , Synbal Inc , Agragene Inc , Division Of Biological Sciences , Tata Institute , Applied Biotechnology , South Asia , Ethan Bier , Director Suresh Subramani ,