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Expelling cancer by squeezing out rogue cells


May 5, 2021 11:00am
MIT biologists reported that the cell elimination process called cell extrusion could offer new insights into stopping cancer. (Vivek Dwivedi)
Cancer cells multiply out of control because they re able to escape a mechanism known as programed cell death. But scientists at the Massachusetts Institute of Technology (MIT) and King’s College London have uncovered key functions of another pathway with a long evolutionary history that the body uses to dispose of those rogue cells.
During this process, called cell extrusion, cells are squeezed out of the lining of tissues. The team, led by Nobel laureate H. Robert Horvitz, Ph.D., found that the process is triggered when cells fail to replicate their DNA during cell division, according to a study published in Nature. ....

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Eyeless roundworms sense color - ScienceBlog.com


Eyeless roundworms sense color
March 5, 2021MIT
Roundworms don’t have eyes or the light-absorbing molecules required to see. Yet, new research shows they can somehow sense color. The study, published on March 5 in the journal 
Science, suggests worms use this ability to assess the risk of feasting on potentially dangerous bacteria that secrete blue toxins. The researchers pinpointed two genes that contribute to this spectral sensitivity and are conserved across many organisms, including humans.
“It’s amazing to me that a tiny worm with neither eyes nor the molecular machinery used by eyes to detect colors can identify and avoid a toxic bacterium based, in part, on its blue color,” says H. Robert Horvitz, the David H. Koch Professor of Biology at MIT, a member of the McGovern Institute for Brain Research and the Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute Investigator, and the co-senior author of the study. “One of ....

Robin Chemers Neustein , Dipon Ghosh , Davidh Koch , Leslie Vosshall , H Robert Horvitz , Mcgovern Institute For Brain Research , Koch Institute For Integrative Cancer Research , Rockefeller University , Howard Hughes Medical Institute Investigator , National Institute , Howard Hughes Medical Institute , Mcgovern Institute , Brain Research , Koch Institute , Integrative Cancer Research , Robin Chemers Neustein Professor , General Medical , ஏச் ராபர்ட் ஹார்விட்ஸ் , மகவர்ந் நிறுவனம் க்கு மூளை ஆராய்ச்சி , கோச் நிறுவனம் க்கு ஒருங்கிணைந்த புற்றுநோய் ஆராய்ச்சி , ராக்ஃபெல்லர் பல்கலைக்கழகம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் புலனாய்வாளர் , தேசிய நிறுவனம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , மகவர்ந் நிறுவனம் , மூளை ஆராய்ச்சி ,

Stuart Orkin receives $500,000 Gruber Genetics Prize for his groundbreaking research on genetics of inherited blood disorders

Stuart Orkin receives $500,000 Gruber Genetics Prize for his groundbreaking research on genetics of inherited blood disorders
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