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Tricking Cellular Powerhouse to Circumvent Chemotherapy Resistance

Inhibition of NLRP3 complex can reduce inflammation in melanoma patients


Inhibition of NLRP3 complex can reduce inflammation in melanoma patients
Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center.
In a paper published in the journal
PNAS last month, CU Cancer Center members Mayumi Fujita, MD, PhD, Angelo D Alessandro, PhD, Morkos Henen, PhD, MS, Beat Vogeli, PhD, Eric Pietras, PhD, James DeGregori, PhD, Carlo Marchetti, PhD, and Charles Dinarello, MD, along with Isak Tengesdal, MS, a graduate student in the Division of Infectious Diseases at the University of Colorado School of Medicine, detail their work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. ....

United States , Eric Pietras , Charles Dinarello , James Degregori , Emily Henderson , Morkos Henen , Carlo Marchetti , Mayumi Fujita , Angelo Dalessandro , University Of Colorado , University Of Colorado School Medicine , University Of Colorado Cancer Center , Division Of Infectious Diseases , Cu Cancer Center , Colorado Cancer , Angelod Alessandro , Beat Vogeli , Isak Tengesdal , Infectious Diseases , Colorado School , ஒன்றுபட்டது மாநிலங்களில் , ஜேம்ஸ் டெக்ரேகோரி , எமிலி ஹென்டர்சன் , கார்லோ மார்ச்செட்டி , மயூமி புஜிதா , ஏஞ்சலோ டாப்லெஸ்ஸான்றோ ,

A drug that can stop tumors from growing


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Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center.
In a paper published in the journal
PNAS last month, CU Cancer Center members Mayumi Fujita, MD, PhD, Angelo D Alessandro, PhD, Morkos Henen, PhD, MS, Beat Vogeli, PhD, Eric Pietras, PhD, James DeGregori, PhD, Carlo Marchetti, PhD, and Charles Dinarello, MD, along with Isak Tengesdal, MS, a graduate student in the Division of Infectious Diseases at the University of Colorado School of Medicine, detail their work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and the resultant tumor expansion. ....

United States , Eric Pietras , Morkos Henen , Charles Dinarello , Angelo Dalessandro , Mayumi Fujita , Carlo Marchetti , James Degregori , University Of Colorado School Medicine , University Of Colorado Cancer Center , Division Of Infectious Diseases , Cu Cancer Center , Colorado Cancer , Angelod Alessandro , Beat Vogeli , Isak Tengesdal , Infectious Diseases , Colorado School , ஒன்றுபட்டது மாநிலங்களில் , ஏஞ்சலோ டாப்லெஸ்ஸான்றோ , மயூமி புஜிதா , கார்லோ மார்ச்செட்டி , ஜேம்ஸ் டெக்ரேகோரி , பல்கலைக்கழகம் ஆஃப் கொலராடோ பள்ளி மருந்து , பல்கலைக்கழகம் ஆஃப் கொலராடோ புற்றுநோய் மையம் , பிரிவு ஆஃப் தொற்று நோய்கள் ,