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Immune cells imperfect at distinguishing between friend and foe, study suggests


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When it comes to distinguishing a healthy cell from an infected one that needs to be destroyed, the immune system s killer T cells sometimes make mistakes.
This discovery, described today in
eLife, upends a long-held belief among scientists that T cells were nearly perfect at discriminating friend from foe. The results may point to new ways to treat autoimmune diseases that cause the immune system to attack the body, or lead to improvements in cutting-edge cancer treatments.
It is widely believed that T cells can discriminate perfectly between infected cells and healthy ones based on how tightly they are able to bind to molecules called antigens on the surface of each. They bind tightly to antigens derived from viruses or bacteria, but less tightly to our own antigens on normal cells. But recent studies by scientists looking at autoimmune diseases suggest that T cells can attack otherwise normal cells if they express unusually large numbers of our own ant ....

United Kingdom , Johannes Pettmann , Omer Dushek , Emily Packer , Anna Huhn , University Of Oxford , Alice Wallenberg Foundation , Sir William Dunn School Of Pathology , Senior Research Fellow In Basic Biomedical Sciences , Times Higher Education World University Rankings , Radcliffe Department Of Medicine , Oxford University Innovation , Max Planck Society , Oxford University , Kennedy Institute , Howard Hughes Medical Institute , Sir William Dunn School , Radcliffe Department , Enas Abu Shah , Postdoctoral Fellow , Associate Professor , Senior Research Fellow , Basic Biomedical Sciences , Wellcome Trust , Media Relations Manager , Systems Biology ,

Evotec invests into Oxford Cell Therapy Company "OxVax"


Evotec invests into Oxford Cell Therapy Company OxVax
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Evotec invests into Oxford Cell Therapy Company OxVax
Evotec is co-leading investment into OxVax, a spinout from Oxford University, which is formed with the objective of producing first-in-class cancer vaccines. 
Hamburg, Germany, 21 April 2021:
Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) announced today that the Company has invested into OxVax, a new immuno-oncology company based on research from Oxford University, which enables the development of the next generation of cancer vaccines with the potential to overcome the limitations of the current approaches.
OxVax is developing an innovative cancer vaccine platform based on a unique and proprietary population of dendritic cells capable of inducing a potent anti-tumour immune response. The company s technology allows the bulk manufacture of these cells from donor blood derived stem ....

Thomas Hanke , Marcelo Bravo , Paulj Fairchild , Tim Davies , Evotec Se Frankfurt Stock Exchange , Oxford University , Frankfurt Stock Exchange , Professor Paulj Fairchild , Sir William Dunn School , Chief Executive Officer , South Korean Based , Lead Compass , Academic Partnerships , Associate Professor , Stem Cells , Chief Executive , Lead Compass Investment , தாமஸ் ஹான்கே , நேரம் டேவிஸ் , ஆக்ஸ்ஃபர்ட் பல்கலைக்கழகம் , பிராங்க்ஃபர்ட் ஸ்டாக் பரிமாற்றம் , ஐயா வில்லியம் டன் பள்ளி , தலைமை நிர்வாகி அதிகாரி , தெற்கு கொரியன் அடிப்படையிலானது , இணை ப்ரொஃபெஸர் , தண்டு செல்கள் ,