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Activity flow underlying abnormalities in brain activations and cognition in schizophrenia

Abstract
Cognitive dysfunction is a core feature of many brain disorders, including schizophrenia (SZ), and has been linked to aberrant brain activations. However, it is unclear how these activation abnormalities emerge. We propose that aberrant flow of brain activity across functional connectivity (FC) pathways leads to altered activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping, an approach that models the movement of task-related activity between brain regions as a function of FC. Using functional magnetic resonance imaging data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in patients. Our results suggest that dysfuncti ....

United States , Los Angeles , Los Angeles County , New Jersey , Yale University , University Of California , Consortium For Neuropsychiatric Phenomics , Slovenian Research Agency , Australian Government National Health , Blackthorn Therapeutics Inc , Research Council Emerging Leader , Los Angeles County Department Of Mental Health , University Of New Jersey , Ahmanson Lovelace Brain Mapping Center Siemens , Staglin Center , Office Of Advanced Research Computing , Technology Advisory Board , Neuropsychiatric Phenomics , Human Connectome Project , Statistical Manual , Mental Disorders , Fourth Edition Text Revision , Structured Clinical Interview , Institutional Review Boards , Los Angeles County Department , Siemens Trio ,

MDMA-Assisted Therapy Offers a Win for PTSD Remission

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An investigative, add-on MDMA-based therapy was effective for improving posttraumatic stress disorder (PTSD) symptoms, according to a phase III trial.
In a randomized controlled trial of 90 adults with severe chronic PTSD, those on MDMA pharmacotherapy plus psychotherapy saw a significant improvement in PTSD symptoms as measured by the clinician-administered CAPS-5 Total Severity Score versus those on placebo and psychotherapy alone (
d=0.91, 95% CI 0.44-1.37,
P ....

New York , United States , American Psychiatric Association , Pamerican Psychiatric Association , Severity Score , Psychiatric Association , Sheehan Disability Scale , Beck Depression Inventory , Breakthrough Therapy , Structured Clinical Interview , Personality Disorders , Columbia Suicide Severity Rating Scale , New York City , Major Depression , Post Traumatic Stress Disorder , Suicidal Ideation , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , அமெரிக்கன் மனநல சங்கம் , தீவிரம் மதிப்பெண் , மனநல சங்கம் , ஷீஹான் இயலாமை அளவு , பெக் மனச்சோர்வு சரக்கு , திருப்புமுனை சிகிச்சை , கட்டமைக்கப்பட்ட மருத்துவ நேர்காணல் , ஆளுமை கோளாறுகள் ,

NIMH » Serious Mental Illness (SMI) Among U.S. Adults

NIMH » Serious Mental Illness (SMI) Among U.S. Adults
nih.gov - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nih.gov Daily Mail and Mail on Sunday newspapers.

United States , National Survey On Drug , Mental Health Findings , Axisi Disorders Research Version , Serious Mental Illness , National Survey , Drug Use , Statistical Manual , Mental Disorders , Structured Clinical Interview , Research Version , Non Patient Edition , Health Findings , ஒன்றுபட்டது மாநிலங்களில் , தேசிய கணக்கெடுப்பு ஆன் மருந்து , மன ஆரோக்கியம் கண்டுபிடிப்புகள் , தீவிரமானது மன உடல் நலமின்மை , தேசிய கணக்கெடுப்பு , மருந்து பயன்பாடு , புள்ளிவிவர கையேடு , மன கோளாறுகள் , கட்டமைக்கப்பட்ட மருத்துவ நேர்காணல் , ஆராய்ச்சி பதிப்பு , ஆரோக்கியம் கண்டுபிடிப்புகள் ,

NIMH » Any Mental Illness (AMI) Among U.S. Adults

Diagnostic Assessment:
The NSDUH AMI estimates are generated from a prediction model created from clinical interview data collected on a subset of adult NSDUH respondents who completed a past 12-month version of the Structured Clinical Interview for the DSM-IV-TR Axis I Disorders (Research Version, Non-patient Edition (SCID-I/NP)).
The assessment included diagnostic modules assessing: mood, anxiety, eating, impulse control, substance use, adjustment disorders, and a psychotic symptoms screen.
The assessment did not contain diagnostic modules assessing: adult attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, schizophrenia or other psychotic disorders (although the assessment included a psychotic symptom screen).
People who only have disorders that are not included in these diagnostic modules may not be adequately detected. However, there are known patterns of high comorbidities among mental disorders; these patterns increase the likelihood ....

United States , National Survey On Drug , National Institute On Drug Abuse , National Institute On Alcohol Abuse , Mental Health Services Administration , Mental Health Findings , Axisi Disorders Research Version , Any Mental Illness , National Survey , Drug Use , Statistical Manual , Mental Disorders , National Institute , Drug Abuse , Alcohol Abuse , Substance Abuse , Structured Clinical Interview , Research Version , Non Patient Edition , Health Findings , ஒன்றுபட்டது மாநிலங்களில் , தேசிய கணக்கெடுப்பு ஆன் மருந்து , தேசிய நிறுவனம் ஆன் மருந்து , மன ஆரோக்கியம் கண்டுபிடிப்புகள் , ஏதேனும் மன உடல் நலமின்மை , தேசிய கணக்கெடுப்பு ,

"A Bridge Between Person-Based Versus Symptom-Based Nosology: A Clinica" by Eleonora Patriarca, Emanuela Brusadelli et al.

Abstract
The Psychodynamic Diagnostic Manual Second Edition (PDM-2) stresses the importance of the integration between a descriptive and functional understanding of clinical phenomena in order to enhance a person-based nosology. The present article aims to discuss a clinical case of a patient suffering from generalized anxiety disorder, currently considered a controversial diagnosis, in order to illustrate some of the complexities and advantages of the PDM-2 model in the psychodiagnostic description, case formulation, and treatment planning. To do so, we applied the Psychodiagnostic Chart Second Edition (PDC-2) to an Adult Attachment Interview (AAI) transcript, and, to the best of our knowledge, this is the first study that pursued this goal. As a clinical-research method, the AAI represents a useful tool in order to explore patients’ mental states and internalized object relations, crucial aspects in personality organization. Furthermore, the Structured Clinical Interview f ....

Psychodynamic Diagnostic Manual , Second Edition , Psychodiagnostic Chart , Adult Attachment Interview , Structured Clinical Interview , Statistical Manual , Mental Disorders , Fourth Edition , Axisi Disorders , Borderline Personality Disorder , Generalized Anxiety Disorder , Sychodiagnostic Chart 2 , Sychodynamic Diagnostic Manual Second Edition , இரண்டாவது பதிப்பு , கட்டமைக்கப்பட்ட மருத்துவ நேர்காணல் , புள்ளிவிவர கையேடு , மன கோளாறுகள் , நான்காவது பதிப்பு ,