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Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication


Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication
In February 2020, a trio of bio-imaging experts were sitting amiably around a dinner table at a scientific conference in Washington, D.C., when the conversation shifted to what was then a worrying viral epidemic in China. Without foreseeing the global disaster to come, they wondered aloud how they might contribute.
Nearly a year and a half later, those three scientists and their many collaborators across three national laboratories have published a comprehensive study in Biophysical Journal that - alongside other recent, complementary studies of coronavirus proteins and genetics - represents the first step toward developing treatments for that viral infection, now seared into the global consciousness as COVID-19. ....

United States , Oak Ridge , Greg Hura , Andrzej Joachimiak , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Protein Data Bank , Berkeley Lab Advanced Light Source , Argonne National Laboratory , Structural Biology Department , Bioimaging Division , Berkeley Lab Molecular Biophysics , Biophysical Journal , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Molecular Biophysics , Integrated Bioimaging , Oak Ridge National Laboratory , Advanced Light Source , Advanced Photon Source , High Flux Isotope Reactor , Spallation Neutron Source , Science National Virtual Biotechnology Laboratory , Added Joachimiak , ஒன்றுபட்டது மாநிலங்களில் ,

The Hunger Games: Uncovering the secret of the hunger switch in the brain


21 Apr 2021
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Ever stood at your refridgerator staring into it and wishing you could switch off the hunger pangs that took you there in the first place? Now, with the help of one family s genetic disposition to suffer uncontrollable and persistent hunger, researchers have uncovered the mechanism of action of the master switch for hunger in the brain shedding new light on the way hunger is regulated. Results have uncovered a 3D structure that reveals how a unique molecular switch in our brain causes us to feel full - and may help develop improved anti-obesity drugs.
Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. ....

Israel General , Peterj Mccormick , Danny Ben Zvi , Moran Shalev Benami , Oksana Degtjarik , Queen Mary University Of London , Hebrew University Of Jerusalem , Weizmann Institute Of Science , Structural Biology Department , Weizmann Institute , Queen Mary University , Hebrew University , Hadar Israeli , Prof Mashay Niv , இஸ்ரேல் ஜநரல் , டேனி பென் ஸ்வை , ராணி மேரி பல்கலைக்கழகம் ஆஃப் லண்டன் , ஹீப்ரு பல்கலைக்கழகம் ஆஃப் ஏருசலேம் , வெய்ஸ்மேன் நிறுவனம் ஆஃப் அறிவியல் , கட்டமைப்பு உயிரியல் துறை , வெய்ஸ்மேன் நிறுவனம் , ராணி மேரி பல்கலைக்கழகம் , ஹீப்ரு பல்கலைக்கழகம் , ஹதர் இஸ்ரேலி ,

Weizmann Institute Uncovers Secret of Hunger Switch in the Brain | The Jewish Press - JewishPress.com | Jewish Press News Desk | 4 Iyyar 5781 – April 16, 2021


Photo Credit: Image by Gerd Altmann from Pixabay
Being constantly hungry, no matter how much you eat – that’s the daily struggle of people with genetic defects in the brain’s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....

Israel General , Moran Shalev Benami , Oksana Degtjarik , Vadivel Prabahar , Gerd Altmann , Yoav Peleg , Fabrizio Fierro , Nicolasj Roth , Vidicha Chunilal , Peterj Mccormick , Lif Chan , Danny Ben Zvi , Amandeep Kaur Gill , Joaquin Botta , Weizmann Institute Of Science , Tauro Career Development , Leadership Program , Wolf Lebovic Lab , Magnetic Resonance Research , Weizmann Life Sciences Core Facilities Department , Queen Mary University Of London , Hebrew University Of Jerusalem , Ilse Katz Institute For Material Sciences , Structural Biology Department , Biomedical Research , Photo Credit ,