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Worldwide network develops SARS-CoV-2 protocols for research laboratories

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IMAGE: Scientists Martin Hengesbach (left) und Andreas Schlundt at the nuclear magnetic resonance (NMR) spectrometre at Goethe-University Frankfurt, Germany.
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Credit: Uwe Dettmar for Goethe-University Frankfurt, Germany
FRANKFURT. When the SARS-CoV-2 virus mutates, this initially only means that there is a change in its genetic blueprint. The mutation may lead, for example, to an amino acid being exchanged at a particular site in a viral protein. In order to quickly assess the effect of this change, a three-dimensional image of the viral protein is extremely helpful. This is because it shows whether the switch in amino acid has consequences for the function of the protein - or for the interaction with a potential drug or antibody. ....

Rio Preto , Santa Catarina , Switzerland General , United States , Frankfurt Am Main , Duque De Caxias , Estado Do Rio , Sesto Fiorentino , Baden Wüberg , Rio De Janeiro , Andreas Schlundt , Halle Saale , Martin Hengesbach , Harald Schwalbe , Charles Tanford Protein Centre , Lyon University , Chemical Biology At Goethe University , Institute Of Organic Chemistry , University Of Rio De Janeiro , Goethe Coronavirus Fund , Institute For Molecular Virology , University Of Florence , Oswaldo Cruz Foundation , Spanish National Research Council , Institute For Biochemistry , Institute Of Medical Biochemistry ,

Andrew Thomson obituary

Last modified on Wed 12 May 2021 23.19 EDT
Andrew Thomson, who has died aged 80 after a stroke, played a crucial role early in his career in the discovery of a widely used anti-cancer drug, cisplatin, before going on to do pioneering work in the field of spectroscopy, enhancing our understanding of the functioning of substances vital to life, such as haemoglobin.
As an Oxford research chemist with a background in platinum chemistry, in 1967 Andrew was invited to Michigan State University by a group of biophysicists who had found that passing an electric current, using platinum electrodes, through a culture of the bacterium E coli had an inhibiting effect on the cell replication. They needed a chemist to determine the active substance. Andrew solved their problem by suggesting and synthesising two potential inhibitors and identifying the active one – now known as cisplatin. ....

United Kingdom , New Zealand , West Sussex , New Zealand General , Buenos Aires , Distrito Federal , Colin Greenwood , Andrew Thomson , Anne Marsden , Wadham College , Royal Society , Norwich Research Park , University Of East Anglia , Centre For Molecular , Michigan State University , Centre For Metalloprotein Spectroscopy , Williams At Oxford University , Oxford University , East Anglia , Metalloprotein Spectroscopy , Structural Biochemistry , Henry Wellcome Unit , ஒன்றுபட்டது கிஂக்டம் , புதியது ஜீலாந்து , மேற்கு சசெக்ஸ் , புதியது ஜீலாந்து ஜநரல் ,

Researchers engineer probiotic yeast to produce beta-carotene

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Researchers have genetically engineered a probiotic yeast to produce beta-carotene in the guts of laboratory mice. The advance demonstrates the utility of work the researchers have done to detail how a suite of genetic engineering tools can be used to modify the yeast.
There are clear advantages to being able to engineer probiotics so that they produce the desired molecules right where they are needed, says Nathan Crook, corresponding author of the study and an assistant professor of chemical and biomolecular engineering at North Carolina State University. You re not just delivering drugs or nutrients; you are effectively manufacturing the drugs or nutrients on site. ....

Abdulkerim Eroglu , Ibrahim Alabri , Junrui Cheng , Deniz Durmusoglu , Scott Collins , National Science Foundation , Helmholtz Institute , Infection Research , Plants For Human Health Institute , Department Of Molecular , Nc State University , Novo Nordisk Foundation , Carolina State University , Nathan Crook , North Carolina State , Ibrahim Al Abri , Structural Biochemistry , Human Health Institute , Chase Beisel , Technology Engineering Computer Science , Biomedical Environmental Chemical Engineering , ஸ்காட் கோலின்ஸ் , தேசிய அறிவியல் அடித்தளம் , தொற்று ஆராய்ச்சி , செடிகள் க்கு மனிதன் ஆரோக்கியம் நிறுவனம் , துறை ஆஃப் மூலக்கூறு ,

Researchers Engineer Probiotic Yeast to Produce Beta-Carotene

Researchers Engineer Probiotic Yeast to Produce Beta-Carotene
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Abdulkerim Eroglu , Ibrahim Alabri , Junrui Cheng , Deniz Durmusoglu , Scott Collins , Infection Research , Plants For Human Health Institute , Department Of Molecular , National Science Foundation , Carolina State University , Helmholtz Institute , Novo Nordisk Foundation , Nathan Crook , North Carolina State , Ibrahim Al Abri , Structural Biochemistry , Human Health Institute , State University , Chase Beisel , ஸ்காட் கோலின்ஸ் , தொற்று ஆராய்ச்சி , செடிகள் க்கு மனிதன் ஆரோக்கியம் நிறுவனம் , துறை ஆஃப் மூலக்கூறு , தேசிய அறிவியல் அடித்தளம் , கரோலினா நிலை பல்கலைக்கழகம் , நாதன் கோடு ,

New study explains Mycobacterium tuberculosis high resistance to drugs and immunity

New study explains Mycobacterium tuberculosis high resistance to drugs and immunity
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Natallia Strushkevich , Institute Of Bioorganic Chemistry , National Academy Of Sciences Belarus , Massachusetts Institute Of Technology , World Health Organization , Research Center , Skoltech Center , Institute Of Biomedical Chemistry , Pirogov Russian National Research Medical University , Institute Of Biological Information Processing , Moscow Institute Of Physics , University Of Tokyo , Assistant Professor , Data Intensive Science , Bioorganic Chemistry , National Academy , Molecular Mechanisms , Age Related Diseases , Moscow Institute , Biomedical Chemistry , Biological Information Processing , Structural Biochemistry , Structural Biology , European Synchrotron Radiation , Massachusetts Institute , தேசிய கலைக்கழகம் ஆஃப் அறிவியல் பெலாரஸ் ,