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New breakthrough research in cancer

Angelina Jolie, who has never had cancer before, decided to have a preventive double mastectomy because she has a BRCA1 gene mutation, which puts her at increased risk for breast cancer. Photo: Filepic/AFP
In 2013, American actress Angelina Jolie, who has never had cancer before, decided to have a preventive double mastectomy because she has a BRCA1 gene mutation, which puts her at increased risk (87%) of developing breast cancer. And, in 2015, she had her ovaries and fallopian tubes removed to reduce her risk of developing ovarian cancer, the disease that killed her mother at the age of just 56.
During that time, there were only two genes that were usually tested for cancer risk in an individual – BRCA1 and BRCA2. ....

United States , United Kingdom , Douglas Easton , Angelina Jolie , Yayasan Petronas , Nur Aishah , Nur Aishah Mohd Taib , Teo Soo Hwang , Yayasan Sime Darby , European Commission , Centre For Cancer Genetic Epidemiology , University Of Cambridge , Subang Jaya Medical Centre , Universiti Malaya Cancer Research Institute , Estee Lauder Group Of Companies , Cancer Research Malaysia , University Of Malaya Medical Centre , Breast Cancer Risk , Diagnostic Gene Sequencing , New England Journal , Malaya Medical Centre , Cancer Research , Professor Douglas Easton , Cancer Genetic Epidemiology , Wellcome Trust , Estee Lauder Group ,

Using gene testing to assess the risk of breast cancer

Using gene testing to assess the risk of breast cancer
Clinicians will soon be able to use gene panel testing to identify those most at risk from developing breast cancer, thanks to 2,000 DNA samples gathered in Ireland and which were used as part of an international study involving more than 113,000 women,
Peter Doyle reports
There are nine specific genes associated with breast cancer risk, according to the results of an international project with significant Irish involvement. The University of Cambridge-led BRIDGES (Breast Cancer Risk after Diagnostic Gene Sequencing) study aimed to identify women at high risk of breast cancer and to develop sensitive and informative gene panel testing for the prediction of breast cancer risk. ....

Nicola Miller , Michael Kerin , Kelvin Gilmor , Peter Doyle , University Of Cambridge , National Breast Cancer Research Institute , Galway School Of Medicine , Association Analysis In More , Breast Cancer Risk , Diagnostic Gene Sequencing , Breast Cancer , Galway Genetics Study , New England Journal , Breast Cancer Risk Genes , Association Analysis , Cancer Managed Clinical Academic Network , Saolta University Health Care Group , நிகோலா மில்லர் , மைக்கேல் கெரின் , கெல்‌விந் கில்மோர் , பீட்டர் டாய்ல் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , தேசிய மார்பக புற்றுநோய் ஆராய்ச்சி நிறுவனம் , கால்வே பள்ளி ஆஃப் மருந்து , சங்கம் பகுப்பாய்வு இல் மேலும் , மார்பக புற்றுநோய் ஆபத்து ,

CNIO participates in a study that defines the most important genes that increase breast cancer risk

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IMAGE: From left to right, CNIO researchers Belén Herráez, Anna González-Neira, Rosario Alonso, Nuria Álvarez, Ana Osorio, Rocío Núñez, Guillermo Pita, and Javier Benítez.
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Credit: A. Garrido, CNIO
Genetic inheritance affects the likelihood of developing breast cancer. Some genes are already known to increase cancer risk; other genes are suspected to be involved, but not to what extent. It is crucial to clarify this issue to improve prevention since it opens the way to more personalised follow-up and screening programs. A large international consortium, which includes the Spanish National Cancer Research Centre (CNIO), has studied 34 putative susceptibility genes on samples from 113,000 female breast cancer cases and controls, and its results confirm the importance of nine of them. ....

United Kingdom , Javier Ben , Anna Gonz , European Union Horizon , Human Genetics Group , Spanish National Cancer Research Centre , Cancer Research United Kingdom , Spanish Ministry Of Science , National Institute Of Health Carlos , New England Journal , Genetics Group , Breast Cancer Risk , Diagnostic Gene Sequencing , Human Genotyping , European Union , Innovation Programme , Wellcome Trust , Cancer Research United , Spanish Ministry , National Institute , Health Carlos , ஒன்றுபட்டது கிஂக்டம் , ஜேவியர் பென் , அண்ணா கோன்ஸ் , ஐரோப்பிய தொழிற்சங்கம் அடிவானம் , மனிதன் ஜெநெடிக்ஸ் குழு ,