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Study offers clues for earlier diagnosis of folate deficiency


Study offers clues for earlier diagnosis of folate deficiency
As many expectant mothers know, getting enough folate is key to avoiding neural tube defects in the baby during pregnancy. But for the individuals who carry certain genetic variants, dealing with folate deficiency can be a life-long struggle which can lead to serious neurological and heart problems and even death.
Now a Donnelly Centre study offers clues to how to recognize early those who are most at risk.
Defects in an enzyme called MTHFR, or 5,10-methylenetetrahydrofolate reductase, which modifies folate, or vitamin B9 as it is also known, to produce other essential cellular components, can increase a person s need for folate. MTHFR deficiency occurs when a person inherits two defective copies of this gene, one from each parent. Disease severity depends on the exact changes in the composition of the amino-acid residues which make up the protein and which are encoded by the two copies of the gene that a pe ....

United States , Fritz Roth , Emily Henderson , Variant Effects Alliance , National Institutes Of Health , Donnelly Centre For Cellular , Canada Excellence Research , Lunenfeld Tanenbaum Research Institute At Sinai Health Systems , A Donnelly Centre , Biomolecular Research , Donnelly Centre , Temerty Faculty , American Journal , Genomic Variation , National Institutes , Senior Investigator , Lunenfeld Tanenbaum Research Institute , Sinai Health Systems , Canada Excellence Research Chair , ஒன்றுபட்டது மாநிலங்களில் , ஃப்ரிட்ஸ் ரோத் , எமிலி ஹென்டர்சன் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , டோநிலீ மையம் க்கு செல்லுலார் , கனடா சிறப்பானது ஆராய்ச்சி , உயிர் மூலக்கூறு ஆராய்ச்சி ,