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Alterations in the 3D genome structure and effects on fertility revealed


Credit: Covadonga Vara and Aurora Ruiz-Herrera, UAB.
The genome is tightly organised (packaged) within the cell nuclei. This three-dimensional (3D) genome organisation is fundamental, given that it regulates gene expression.
A study led by scientists at the Universitat Autònoma de Barcelona (UAB) now demonstrates using mice models that the 3D organisation of the genome is extremely dynamic during the formation of male germ cells (precursors of spermatozoa) and that alterations in this structure can affect fertility.
The research, published in
Nature Communications, describes the 3D genome organisation in germ cells of wild populations of house mice (Mus musculus domesticus) with chromosomal rearrangements, alterations in the genome which change the structure of chromosomes. The study represents a significant advance in research into mechanisms generating and regulating the structure and function of the genome during the formation of gametes (oocytes and sperm ....

Comunidad Autonoma De Cataluna , Covadonga Vara , Aurora Ruiz Herrera , Nature Communications , Department Of Cellular Biology , National Centre For Genomic Analysis , Centre For Genomic Regulation , Institute Of Biotechnology , Cornell University United States , Department Of Animal Biology , Universitat Aut , Associated Professor , Cellular Biology , Animal Biology , Plant Biology , National Centre , Genomic Analysis , Genomic Regulation , Sequentia Biotech , Cornell University , United States , Cell Biology , Developmental Reproductive Biology , காமுனிடட தன்னாட்சி டி கடலுள் , அரோரா ர்டீஸ் ஹெர்ரெரா , இயற்கை தகவல்தொடர்புகள் ,

How the fly selects its reproductive male - Communiqués de presse


How the fly selects its reproductive male
Researchers from UNIGE have discovered a very small protein in Drosophila that plays a key role in how females select the semen that will fertilize its eggs when it mates with several males.
Drosophila accessory glands consisting of two cell types (green “secondary cells” surrounded by red nuclei of the “main cells”). © Robert Maeda
Even a well-characterized genome, such as that of the Drosophila the so-called fruit fly, still holds surprises. A team from the University of Geneva (UNIGE), Switzerland, in collaboration with Cornell University (USA) and the University of Groningen (Netherlands), has discovered an RNA coding for a micro-peptide – a very small protein – that plays a crucial role in the competition between spermatozoa from different males with which the female mates. In addition to shedding new light on this biological mechanism, this work, to be read in the journal ....

Robert Maeda , University Of Groningen Netherlands , Proceedings Of The National Academy Sciences , University Of Geneva , Cornell University United States , Department Of Genetics , Cornell University , United States , National Academy , ராபர்ட் மாயீட , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் நெதர்லாந்து , பல்கலைக்கழகம் ஆஃப் ஜிநீவ , கார்னெல் பல்கலைக்கழகம் ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் ஜெநெடிக்ஸ் , கார்னெல் பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , தேசிய கலைக்கழகம் ,

How the fly selects its reproductive male | EurekAlert! Science News


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IMAGE: Drosophila accessory glands consisting of two cell types (green secondary cells surrounded by red nuclei of the main cells ).
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Credit: © Robert Maeda
Even a well-characterized genome, such as that of the Drosophila the so-called fruit fly, still holds surprises. A team from the University of Geneva (UNIGE), Switzerland, in collaboration with Cornell University (USA) and the University of Groningen (Netherlands), has discovered an RNA coding for a micro-peptide - a very small protein - that plays a crucial role in the competition between spermatozoa from different males with which the female mates. In addition to shedding new light on this biological mechanism, this work, to be read in the journal ....

Robert Maeda , University Of Groningen Netherlands , Proceedings Of The National Academy Sciences , University Of Geneva , Cornell University United States , Department Of Genetics , Cornell University , United States , National Academy , ராபர்ட் மாயீட , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் நெதர்லாந்து , பல்கலைக்கழகம் ஆஃப் ஜிநீவ , கார்னெல் பல்கலைக்கழகம் ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் ஜெநெடிக்ஸ் , கார்னெல் பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , தேசிய கலைக்கழகம் ,