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Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer

Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies. ....

New York , United States , Dana Farber Cancer Institute , New South Wales , Benjamin Blyth , Otto Kauko , Jenniferr Devlin , Saraha Welsh , Elisa Barbieri , Kaylenej Simpson , Edwind Hawkins , Michael Ohlmeyer , Deboraha Knight , Matteo Costacurta , Stefan Bjelosevic , Gareth Gregory , Simonj Hogg , Ricky Johnstone , Elena Demosthenous , Magnus Zethoven , Jarrodj Sandow , Benp Martin , Conorj Kearney , Izabela Todorovski , Joseph Ha Vissers , Madisonj Kelly ,

We Are Social launches virtual pirate in new ARRRR filter for The Kids' Cancer Project

May 14, 2021 10:36
Charity The Kids’ Cancer Project has created an AR filter, the ARRRR filter, in a new pro bono campaign via We Are Social.
The Facebook and Instagram filter changes the user into a pirate in support of Pirate Day 2021, today (14 May).
The Kids’ Cancer Project AR filter for Pirate Day 2021
Pirate Day is an annual fundraiser for The Kids Cancer Project, which looks to raise money to put toward research for better treatment for children’s brain cancer.
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By entering a code after donating at PirateDay.com.au, users can unlock Rosie the parrot in the filter. The filter can be found on The Kids Cancer Project’s Instagram page. The socially-led agency has enlisted influencers Olivia Vivian, Ben Poulson, and Mel Schilling to promote the campaign and encourage others to donate. ....

Ewan Harvey , Ben Poulson , Anna Macdonald , Mel Schilling , Olivia Vivian , Bluefocus Intelligent Communication Group , Australian National University , Charity The Kid Cancer Project , Pirate Day , Kids Cancer Project , Are Social , Kid Cancer Project , Ewan Harveythe Kid Cancer Projectwe Are , ய்வந் ஹார்வி , அண்ணா மெக்டொனால்ட் , மெல் ஸ்சில்லீங் , ஒலிவியா விவியன் , ஆஸ்திரேலிய தேசிய பல்கலைக்கழகம் , கொள்ளையர் நாள் , கீட்ஸ் புற்றுநோய் ப்ராஜெக்ட் , உள்ளன சமூக , கிட் புற்றுநோய் ப்ராஜெக்ட் ,

The Kids' Cancer Project invites Australians to donate in new campaign via We Are Social

May 14 2021, 8:58 am | BY Ricki Green | No Comments
Socially-led creative agency We Are Social has partnered with visual effects company Alt.VFX to offer pro-bono support to The Kids’ Cancer Project, independent Australian charity that in 2015 launched Pirate Day, a day of dressing up to raise funds for childhood brain cancer research.

The Kids’ Cancer Project uses money raised from Pirate Day to fund scientific studies that look into better treatments and ultimately a cure for brain cancer, which is the biggest killer by disease amongst children.
The socially-led Pirate Day campaign, aimed at driving awareness and inviting Australians to donate, offers an opportunity for people to virtually dress up as a pirate and show their support online using #PirateDay2021. ....

Ewan Harvey , Mel Schilling , Ben Polson , Thekidscancerproject Instagram , Olivia Vivian , Are Social , Kid Cancer Project , Pirate Day , ய்வந் ஹார்வி , மெல் ஸ்சில்லீங் , பென் போல்ஸந் , ஒலிவியா விவியன் , உள்ளன சமூக , கிட் புற்றுநோய் ப்ராஜெக்ட் , கொள்ளையர் நாள் ,

World-first clinical trial targets immune molecule IL23 as p

World-first clinical trial targets immune molecule IL23 as p
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

New South Wales , Maya Kansara , David Thomas , Garvan Institute , Office Of Health , Immunobiology Of Cancer Group , Kinghorn Cancer Centre , University Of Sydney , Garvan Institute Of Medical Research , Matthew Fisher Sarcoma Research Fund , Omico The Australian Genomic Cancer Medicine Centre , Clinical Trials Centre , Brading Foundation , Medical Research , Australian Genomic Cancer Medicine Centre , Trials Centre , Cooper Rice Brading Foundation , Australian Government , Kid Cancer Project , Daniel Allchin Race , Molecular Screening , Professor David Thomas , Genomic Cancer Medicine Laboratory , Cancer Group , புதியது தெற்கு வேல்ஸ் , மாயா கன்சாரா ,

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Owen Finegan , Claire Bermingham , Irina Vetter , Hana Starobova , Kate Schroder , Emily Henderson , Institute For Molecular Bioscience , University Of Queensland , Molecular Bioscience , Kid Cancer Project , Lennox Head , Professor Kate , ஓவந் பினேகன் , இரினா வெடர் , கேட் ஸ்க்ரோடர் , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு மூலக்கூறு உயிர் அறிவியல் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , மூலக்கூறு உயிர் அறிவியல் , கிட் புற்றுநோய் ப்ராஜெக்ட் , லெனாக்ஸ் தலை , ப்ரொஃபெஸர் கேட் ,