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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues


Kids armed with anti-coronavirus B cells
It remains unclear whether B cell repertoires against coronaviruses and other pathogens differ between adults and children and how important these distinctions are. Yang
et al. analyzed blood samples from young children and adults, as well as tissues from deceased organ donors, characterizing the B cell receptor (BCR) repertoires specific to six common pathogens and two viruses that they had not seen before: Ebola virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children had higher frequencies of B cells with convergent BCR heavy chains against previously encountered pathogens and higher frequencies of class-switched convergent B cell clones against SARS-CoV-2 and related coronaviruses. These findings suggest that encounters with coronaviruses in early life may produce cross-reactive memory B cell populations that contribute to divergent COVID-19 susceptibilities. ....

United States , Abcellera Biologics , Cour Pharma , World Allergy Organization , Tolerance Network , Crown Family Foundation , National Institutes Of Health , Donor Network , California Transplant Donor Network , Creative Commons Attribution , Donor Network West , Meso Scale Diagnostics , Meso Scale , Before Brands , Immune Tolerance Network , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , நீதிமன்றம் பார்மா , உலகம் ஒவ்வாமை ஆர்கநைஸேஶந் , சகிப்புத்தன்மை வலைப்பின்னல் , கிரீடம் குடும்பம் அடித்தளம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , நன்கொடையாளர் வலைப்பின்னல் , கலிஃபோர்னியா மாற்று நன்கொடையாளர் வலைப்பின்னல் , நன்கொடையாளர் வலைப்பின்னல் மேற்கு , மீசோ அளவு பரிசோதனை ,

COVID-19 may result in prolonged infection in immunocompromised children and young adults


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Children and young adults with compromised immune systems, such as those undergoing cancer treatment, may experience a prolonged period of infection with SARS-CoV-2, the virus that causes COVID-19, and the extended duration of infection may increase the incidence of mutations. This case study was conducted by investigators at Children s Hospital Los Angeles and is published in the journal
Most people are infectious for about 10 days after first showing COVID-19 symptoms. In this study, researchers describe two children and a young adult with acute lymphoblastic leukemia who tested positive for SARS-CoV-2 for months. This is the first report of prolonged infection in a pediatric or young adult population. ....

Stanford University , United States , Los Angeles , Maggie Li , Scottd Boyd , Alexanderr Judkins , Chunhong Huang , Lishuang Shen , Jaclyna Biegel , Jenniferh Han , Dennist Maglinte , Paibel Aguayo Hiraldo , Xiaowu Gai , Moiz Bootwalla , Andrew Pekosz , Thaot Truong , Jennifer Dien Bard , Alex Ryutov , Benjamina Pinsky , Oliverf Wirz , Lior Goldberg , Rebecca Yee , Utsav Pandey , Deepa Bhojwani , Maurice Ogorman , Dien Bard ,

COVID-19 severity affected by proportion of antibodies targeting crucial viral protein


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COVID-19 antibodies preferentially target a different part of the virus in mild cases of COVID-19 than they do in severe cases, and wane significantly within several months of infection, according to a new study by researchers at Stanford Medicine.
The findings identify new links between the course of the disease and a patient s immune response. They also raise concerns about whether people can be re-infected, whether antibody tests to detect prior infection may underestimate the breadth of the pandemic and whether vaccinations may need to be repeated at regular intervals to maintain a protective immune response.
This is one of the most comprehensive studies to date of the antibody immune response to SARS-CoV-2 in people across the entire spectrum of disease severity, from asymptomatic to fatal, said Scott Boyd, MD, PhD, associate professor of pathology. We assessed multiple time points and sample types, and also analyzed levels of viral RNA in patient na ....

United States , Oliver Wirz , Arjun Rustagi , Jennifer Cochran , Chunhong Huang , Monali Manohar , Catherine Hogan , Javaria Najeeb , Catherine Blish , Robert Tibshirani , Angela Rogers , Peter Kim , Justin Manalac , Kari Nadeau , Hannah Wang , Saurabh Gombar , Abigail Powell , James Zehnder , Nigam Shah , Theodore Jardetzky , Benjamin Pinsky , Bryan Stevens , Taia Wang , Scott Boyd , Balasubramanian Narasimhan , Fumiko Yamamoto ,