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Frontiers | Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients


2Luebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany
3General Surgery Department, Tawam Hospital, SEHA, Al Ain, United Arab Emirates
4Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
5Department of Genetics and Molecular Biology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
6Department of Respiratory Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates
7Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada
8Division of Surgery and Interventional Science, University College London, London, United Kingdom
As one of the current global health conundrums, COVID-19 pandemic caused a dramatic increase of cases exceeding 79 million and 1.7 million deaths worldwide. Severe presentation of COVID-19 is characterized by cytokine storm and chronic inflammation resulting in multi-organ dysfunction. Curre ....

South Korea , Ash Shariqah , United Arab Emirates , Abu Dhabi , Abuz Aby , Gholamrezanezhada Extrapulmonary , Clin Chim Acta , Acta Haematologica , Cortijoj Mucins , Argininosuccinate Synthetase , Minghimr Interactivenn , Albrechtm Altanalyze , Fitzeg Hsp , Deutsche Forschungsgemeinschaft , Lysophosphatidylcholine Acyltransferase , J Physiol Endocrinol , Abu Dhabi Health , Research Ethics , Research Ethics Committee , Nuclear Receptors , German Research Foundation Under Germany Excellence Strategy , World Health Organization , Sharjah Research Academy Grant , University Of Sharjah , Their Association With Disease Outcomes In Severe , Dubai Scientific Research Ethics Committee ,

IOF and IFCC review calls for harmonization of assays for reference bone turnover markers


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Bone turnover markers (BTMs) in blood and urine are useful tools in monitoring osteoporosis treatment effects and may be useful for improving patient adherence.
In 2011, a Joint Committee on Bone Metabolism of the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) designated Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood as reference bone turnover markers for bone formation and bone resorption, respectively, in osteoporosis. However, the effective clinical implementation of these recommendations requires the standardization/harmonization of commercial assays [1].
As well as a review of the structures of PINP and β-CTX molecules, the authors provide a succinct, referenced summary of current commercial assays, their descriptions, and performance characteristics. Key characteristics and performance specifications of the fou ....

Clin Chim Acta , Samuel Vasikaran , Nicholas Harvey , Committee For Bone Metabolism , International Osteoporosis Foundation , Committee Of Bone Markers , Committee Of Scientific Advisors , Laboratory Medicine , International Federation Of Clinical Chemistry , Committee On Bone Metabolism , Joint Committee , Bone Metabolism , International Federation , Clinical Chemistry , Professor Samuel Vasikaran , Etienne Cavalier , Bone Markers , Scientific Advisors , Clin Chim , Medicine Health , Internal Medicine , Metabolism Metabolic Diseases , Orthopedic Medicine , Pharmaceutical Chemistry , கிளினிக் சிம் ஆக்டா , சாமுவேல் வாசீகரன் ,