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Ferroptosis Gene Signature in Hepatocellular Carcinoma

Ferroptosis Gene Signature in Hepatocellular Carcinoma
dovepress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dovepress.com Daily Mail and Mail on Sunday newspapers.

United States , Immunome Atlas , Shanghai Cell Bank , Third Affiliated Hospital Of Sun Yat Sen University , Chinese Academy Of Sciences , Cancer Genome Atlas , Gene Expression Omnibus , Third Affiliated Hospital , Sun Yat Sen University , Ethics Committee , Sun Yat Sen , Gene Ontology , Kyoto Encyclopedia , Gene Set Enrichment , Differentially Expressed , Metabolism Related Genes , Molecular Signatures Database , Gene Set Enrichment Analysis , Nomogram Construction , Between Risk Score Model , Immune Checkpoint Genes , Cancer Immunome Atlas , Chinese Academy , Selleck Chemicals , Quantitative Real Time Polymerase Chain Reaction , Transcriptor First Strand ,

FSTL3 is a prognostic biomarker in gastric cancer

DSCAM-AS1 and miR-122-5p.
Although there has been a small amount of research on FSTL3, the exact mechanism by which
FSTL3 functions as an oncogene remains unclear to date. Therefore, in the present study, we aimed to explore the molecular mechanism of
FSTL3 involvement in gastric carcinogenesis and development, and to evaluate its value as a prognostic biomarker and potential therapeutic target for GC.
Materials and Methods
Cell Culture
AGS (moderately differentiated GC cells), HGC-27 (undifferentiated GC cells), GES-1 (healthy gastric epithelial cells), and THP-1 cells (human monocytic cells) were purchased from the cell bank of the Chinese Academy of Sciences (Shanghai, China). MKN-74 and MKN-45 cells (well-differentiated and poorly differentiated GC cells, respectively) were purchased from the Japanese Collection of Research Bioresources Cell Bank. GC cells were cultured in RPMI-1640 medium (Gibco, USA, Lot: 8121248) supplemented with 10% fetal bovine ....

United States , United Kingdom , American Joint Committee On Cancer , Graphpad Software Inc , Antibody Sampler Kit Cell Signaling Technology , Aaf Association , Chinese Academy Of Sciences Shanghai , Japanese Collection Of Research Bioresources Cell Bank , Genechem Corporation Shanghai , Colorful Gene Biological Technology , National Comprehensive Cancer Network , Chinese Academy , Japanese Collection , Research Bioresources Cell , Vector Construction , Genechem Corporation , Beyotime Biotechnology , Sampler Kits , Sampler Kit , Cell Signaling Technology , Zhongshan Golden Bridge Biotechnology , Linked Immunosorbent Assay , Jiangsu Provincial Hospital , Traditional Chinese , American Joint Committee , Jiangsu Province Hospital ,

Vitamin D deficiency exacerbates UV/endorphin and opioid addiction

The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia and reward responses triggered by ultraviolet (UV) radiation are repressed by VitD signaling, suggesting that a feedback loop exists whereby VitD deficiency produces increased UV/endorphin-seeking behavior until VitD levels are restored by cutaneous VitD synthesis. This feedback may carry the evolutionary advantage of maximizing VitD synthesis. However, unlike UV exposure, exogenous opioid use is no ....

United States , Santa Clara , Allen Brian Atlas , National Health , Sheldong Adelson Medical Research Foundation , John Wayne Cancer Institute Sequencing Center , Rosztoczy Foundation Scholarship Program , National Survey On Drug , Laboratories Inc , Soltego Inc , Research Diets Inc , Nutrition Examination , Committee At Massachusetts , National Survey , Drug Use , Nutrition Examination Survey , Massachusetts General Hospital , Some Vitd Deficient , Dietary Vitd , Rescuing Vitd , New Brunswick , Harlan Bioproducts , Institutional Animal Care , Use Committee , Massachusetts General , Inhibitory Units ,

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro
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Sanchari Sinha Dutta , Gene Set Enrichment Analysis , Image Credit , சஞ்சரி சீன்ஹா தத்தா , கீந் அமை செறிவூட்டல் பகுப்பாய்வு , படம் கடன் ,

[Full text] Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing F

1
1Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China;
2Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, Liaoning, People’s Republic of China
Correspondence: Rui Ma
Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China
Background: Lung cancer is one of the most aggressive tumors with high incidence and mortality, which could be classified into lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). Overexpression of Plakophilin-2 (PKP2) has been reported in multiple malignancies. However, the expression and function mechanism of PKP2 in LUAD remain illusive. ....

Eteläuomen Läi , United States , Trizol Invitrogen , People Republic Of China National Standard , Cancer Hospital Of China Medical University , Cell Bank , Cancer Hospital , China Medical University , Institutional Ethical Review Board , China Medical , Ichina National Standard , Type Culture Collection , Chinese Academy , Modified Eagle , Shanghai Genepharma , Prime Script , Cell Signaling Tech , Quantity One , Institutional Animal Care , Use Committee , Graphpad Prism , Supplementary Table , Cell Proliferation , Lung Cancer , Molecular Signatures Database , Kyoto Encyclopedia ,