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Gene Transcription Fine Tuned by New Checkpoint Mechanism


Gene Transcription Fine Tuned by New Checkpoint Mechanism
Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program at The Wistar Institute, in his lab. [Wistar Institute]
May 18, 2021
Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program at The Wistar Institute, in his lab. [Wistar Institute]
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Researchers from the Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, say they have discovered a new checkpoint mechanism that fine-tunes gene transcription.
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). ....

United States , Ricky Johnstone , Alessandro Gardini , Cancer Research , Gene Expression Regulation Program , Sir Peter Maccallum Department Of Oncology , University Of Melbourne , Peter Maccallum Cancer Centre , Peter Maccallum Cancer Center , Wistar Institute , Gene Expression , Regulation Program , Sir Peter Maccallum Department , Protein Phosphatase , ஒன்றுபட்டது மாநிலங்களில் , புற்றுநோய் ஆராய்ச்சி , கீந் வெளிப்பாடு ஒழுங்குமுறை ப்ரோக்ர்யாம் , ஐயா பீட்டர் மக்காலம் துறை ஆஃப் புற்றுநோயியல் , பல்கலைக்கழகம் ஆஃப் மெல்போர்ன் , பீட்டர் மக்காலம் புற்றுநோய் மையம் , கீந் வெளிப்பாடு , ஒழுங்குமுறை ப்ரோக்ர்யாம் , ஐயா பீட்டர் மக்காலம் துறை ,

Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer


Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies. ....

New York , United States , Dana Farber Cancer Institute , New South Wales , Benjamin Blyth , Otto Kauko , Jenniferr Devlin , Saraha Welsh , Elisa Barbieri , Kaylenej Simpson , Edwind Hawkins , Michael Ohlmeyer , Deboraha Knight , Matteo Costacurta , Stefan Bjelosevic , Gareth Gregory , Simonj Hogg , Ricky Johnstone , Elena Demosthenous , Magnus Zethoven , Jarrodj Sandow , Benp Martin , Conorj Kearney , Izabela Todorovski , Joseph Ha Vissers , Madisonj Kelly ,

RNA editing protein ADAR1 protects telomeres and supports proliferation in cancer cells


Credit: The Wistar Institute
PHILADELPHIA (March 12, 2021) Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome stability at chromosome ends and is required for continued proliferation of cancer cells. These findings, reported in
Nature Communications, reveal an additional oncogenic function of ADAR1 and reaffirm its potential as a therapeutic target in cancer.
The lab of Kazuko Nishikura, Ph.D., professor in the Gene Expression & Regulation Program of The Wistar Institute Cancer Center, was one of the first to discover ADAR1 in mammalian cells and to characterize the process of RNA editing and its multiple functions in the cell. ....

United States , Yusuke Shiromoto , Moeko Minakuchi , Masayuki Sakurai , Kentaro Ariyoshi , Kazuko Nishikura , Nature Communications , National Cancer Institute , National Institutes Of Health , Cancer Center , Gene Expression Regulation Program , Japan Society For The Promotion Of Science , Wistar Institute , Uehara Memorial Foundation , Wistar Institute Cancer Center , Cancer Center Support Grant , Gene Expression , Regulation Program , National Institutes , Emerson Collective , Japan Society , Uehara Memorial , ஒன்றுபட்டது மாநிலங்களில் , இயற்கை தகவல்தொடர்புகள் , தேசிய புற்றுநோய் நிறுவனம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,

EGR1 Inhibits Pro-Inflammatory Gene Expression in Macrophages


EGR1 Inhibits Pro-Inflammatory Gene Expression in Macrophages
January 14, 2021
Researchers at The Wistar Institute say they have discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation.
The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions, according to the scientists, who published their study “EGR1 is a gatekeeper of inflammatory enhancers in human macrophages” in ....

Avery Zucco , Alessandro Gardini , Gene Expression Regulation Program , Wistar Institute , Early Growth Response , Gene Expression , Regulation Program , காவேரி ஜுக்கோ , கீந் வெளிப்பாடு ஒழுங்குமுறை ப்ரோக்ர்யாம் , ஆரம்ப வளர்ச்சி பதில் , கீந் வெளிப்பாடு , ஒழுங்குமுறை ப்ரோக்ர்யாம் ,