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Post-MI Outcomes Worse in RA


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Patients with rheumatoid arthritis (RA) were at risk for long-term poor outcomes after myocardial infarction (MI), Finnish researchers found.
The cumulative all-cause mortality during 14 years of follow-up after MI among RA patients was 80.4% compared with 72.3% among matched controls, for a hazard ratio of 1.25 (95% CI 1.16-1.35,
P 0.0001), according to Antti Palomäki, MD, PhD, of Turku University Hospital in Turku, Finland, and colleagues.
Factors that were associated with increased mortality among RA patients were duration of RA (HR 1.06, 95% CI 1.04-1.09,
P 0.0001) per 5-year increment, use of corticosteroids (HR 1.27, 95% CI 1.11-1.45,
P 0.001), and corticosteroid dosage per 1 mg/day (HR 1.05, 95% CI 1.02-1.08, ....

Care Register , Heart Disease , Rheumatoid Arthritis , பராமரிப்பு பதிவு , இதயம் நோய் , முடக்கு கீல்வாதம் ,

Scientists reprogram a common bacterium to make designer sugar-based drug


Scientists reprogram a common bacterium to make designer sugar-based drug
Envisioning an animal-free drug supply, scientists have -; for the first time -; reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in
Nature Communications, the researchers modified
E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.
Genetically engineered
E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules -; called sulfated glycosaminoglycans -;that are often used as drugs and nutraceuticals.. ....

Jonathan Dordick , Deepak Vashishth , Robert Linhardt , Mattheos Koffas , Emily Henderson , Nature Communications , Rensselaer Polytechnic Institute , Rensselaer Polytechnic , E Coli , தீபக் வஷிஷ்ட் , ராபர்ட் லின்ஹார்ட் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ரென்சீலர் பாலிடெக்நிக் , ஏ கோலி ,

Researchers develop mutant gene-targeted immunotherapy approach to fight cancers


Researchers develop mutant gene-targeted immunotherapy approach to fight cancers
A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new antibodies against genetically altered proteins to target cancers.
The researchers targeted their immunotherapy approach to alterations in the common cancer-related p53 tumor suppressor gene, the RAS tumor-promoting oncogene or T-cell receptor genes. They also tested the therapy on cancer cells in the laboratory and in animal tumor models. Their findings are reported in three related studies published March 1 in
Science Immunology, ....

Emily Han , Emily Henderson , Bert Vogelstein , Suman Paul , Kenneth Kinzler , Katharine Wright , Alex Pearlman , Jacqueline Douglass , Sandra Gabelli , Johns Hopkins , Chung Hsiue , Bloomberg Kimmel Institute For Cancer Immunotherapy , Johns Hopkins Kimmel Cancer Center , Ludwig Center , Experimental Therapeutics For The Ludwig Center , Johns Hopkins University School Of Medicine , Howard Hughes Medical Institute , Lustgarten Laboratory , Kimmel Institute , Science Immunology , Science Translational , Johns Hopkins University School , Emily Han Chung Hsiue , Johns Hopkins Report , Senior Author , Associate Professor ,

Combo Therapy Boosts Response in Uncontrolled Gout


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The addition of an immunomodulating agent to pegloticase (Krystexxa) among patients with uncontrolled gout significantly improved response rates, a systematic literature review found.
In a cohort of patients whose gout had been refractory to conventional therapy, co-treatment with pegloticase plus an immunomodulator was associated with an overall response rate of 82.9%, reported Robert T. Keenan, MD, of Duke University in Durham, North Carolina, and colleagues.
That rate was markedly higher than the 42% that had been observed for pegloticase monotherapy in clinical trials, Keenan and co-authors noted in their study online in
Pegloticase is approved for patients with chronic gout who have inadequate serum urate control with xanthine oxidase inhibitors at the highest medically appropriate dose or in whom these drugs are contraindicated. ....

North Carolina , United States , Robertt Keenan , Duke University In Durham , Duke University , Arth Rheum , Movement Disorder , Rheumatoid Arthritis , வடக்கு கரோலினா , ஒன்றுபட்டது மாநிலங்களில் , டியூக் பல்கலைக்கழகம் இல் டர்ஹாம் , டியூக் பல்கலைக்கழகம் , ஆர்த் வாதம் , இயக்கம் கோளாறு , முடக்கு கீல்வாதம் ,