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Study: Abundance of iron can drive cancer cell death in neuroblastoma


Study: Abundance of iron can drive cancer cell death in neuroblastoma
Neuroblastoma is a cancer that develops in nerve tissue, most commonly in the glands around the kidneys. The gene MYCN is overexpressed in 20-25% of neuroblastoma, and MYCN-amplified neuroblastoma contributes to a considerable percentage of pediatric cancer-related deaths.
Anthony Faber, Ph.D., and a team of researchers at VCU Massey Cancer Center were awarded a grant from the American Cancer Society to study how MYCN and an abundance of iron can drive cancer cell death in neuroblastoma and potentially be targeted with novel treatments. This award is the first part of a potential two-stage grant worth a combined total of $600,000. ....

United States , Anthony Faber , Konstantinos Floros , Johnr Congdon , Jennifer Koblinski , Emily Henderson , Mission Boost Grant , Cancer Research , Philips Institute For Oral Health Research , Virginia Commonwealth University , Massey Cancer Center , American Cancer Society , School Of Dentistry , Cancer Center , Developmental Therapeutics , Philips Institute , Oral Health Research , Virginia Commonwealth , Cancer Mouse Models Core , Cell Death , Rheumatoid Arthritis , ஒன்றுபட்டது மாநிலங்களில் , அந்தோணி ஃபேபர் , எமிலி ஹென்டர்சன் , பணி ஊக்க மானியம் , புற்றுநோய் ஆராய்ச்சி ,

Inflammatory Bowel Disease: Enormous Burden for Patients


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In the years 2015 and 2016, U.S. adults with inflammatory bowel disease (IBD) used significantly more health services than their non-IBD counterparts, according to the National Center for Health Statistics.
For the study, Emily P. Terlizzi, MPH, and colleagues compared healthcare usage for persons age 18 and older with and without IBD based on the 2015 and 2016 National Health Interview Surveys (NHIS). The results relied on self-reported data for a total of 66,610 sampled respondents.
Overall, adults with IBD were more likely to have visited any doctor or mental health provider in the past 12 months, and the condition was also associated with a higher prevalence of being prescribed medication. ....

Emilyp Terlizzi , Michaeld Kappelman , National Health Interview Surveys , National Center , University Of North Carolina At Chapel Hill , Natl Health Stat , National Health Statistics , Health Statistics , Health Interview Surveys , North Carolina , Chapel Hill , Health Stat Reports , Inflammatory Bowel Disease , Crohn 039 S , Crohn 039s Disease , Ulcerative Colitis , தேசிய ஆரோக்கியம் நேர்காணல் ஆய்வுகள் , தேசிய மையம் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா இல் தேவாலயம் மலை , நட்டில் ஆரோக்கியம் ஸ்ட்யாட் , தேசிய ஆரோக்கியம் புள்ளிவிவரங்கள் , ஆரோக்கியம் புள்ளிவிவரங்கள் , ஆரோக்கியம் நேர்காணல் ஆய்வுகள் , வடக்கு கரோலினா , தேவாலயம் மலை , ஆரோக்கியம் ஸ்ட்யாட் அறிக்கைகள் ,

Combo Tx for RA Raises Fracture Risk


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Patients with rheumatoid arthritis (RA) who were treated with oral glucocorticoids and proton pump inhibitors (PPIs) were at increased risk for osteoporotic fracture, a large cohort study found.
Patients who were concomitant users of glucocorticoids and PPIs had a 1.6-fold increased risk of osteoporotic fracture (adjusted HR 1.60, 95% CI 1.35-1.89), reported Frank de Vries, PharmD, PhD, of Utrecht University in the Netherlands, and colleagues.
In contrast, for those who used either oral glucocorticoids or PPIs alone, the risk was only 1.2-fold higher. For glucocorticoid use alone, the adjusted hazard ratio was 1.23 (95% CI 1.03-1.47), while for PPI use the hazard ratio was 1.22 (95% CI 1.05-1.42), which were statistically lower than for concomitant use of the two, according to the team s study online in ....

Utrecht University , Uk Clinical Practice Research Datalink , Frank De Vries , Practice Research Datalink , Fracture Of Bone , Rheumatoid Arthritis , அட்ரெக்ட் பல்கலைக்கழகம் , வெளிப்படையான டி வ்ரீஸ் , எலும்பு முறிவு ஆஃப் எலும்பு , முடக்கு கீல்வாதம் ,

Discovery offers potential for stripping tumors of T cell protection


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Discovery offers potential for stripping tumors of T cell protection
First author Seon Ah Lim, Ph.D., and corresponding author Hongbo Chi, Ph.D., both of St. Jude Immunology, contributed to research that raises the potential for treatments that render tumors more vulnerable to cancer immunotherapy.
Immunologists at St. Jude Children’s Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system. Surprisingly, the mechanism does not affect regulatory T cell function outside the tumor and may therefore limit the immune-associated toxicities of targeting regulatory T cells. ....

Gustavo Palacios , Nicole Chapman , Hongbo Chi , Zhao Shi , Wei Su , Jun Wei , Peter Vogel , Yogesh Dhungana , Jordy Saravia , National Institutes Of Health , Jude Children Research Hospital , Seon Ah Lim , Jude Children , Research Hospital , Thanh Long Nguyen , Lingyun Long , National Institutes , St Jude Children 039s Research Hospital , Head And Neck Cancer , Rheumatoid Arthritis , Autoimmune Diseases , Immune Responses , Breast Cancer , Anti Cancer , குஸ்டாவோ பாழசிோஸ் , நிக்கோல் சாப்மேன் ,

Magnesium-based micromotors used to improve rheumatoid arthritis symptoms


Magnesium-based micromotors used to improve rheumatoid arthritis symptoms
Rheumatoid arthritis is a chronic inflammatory disorder marked by joint pain, swelling and damage. Although medications, such as steroids, anti-inflammatory drugs and immunosuppressants, can help slow joint destruction and relieve pain, they have side effects and aren t completely successful.
Now, researchers reporting in ACS
Nano Letters have developed magnesium-based micromotors propelled by hydrogen bubbles, which improved rheumatoid arthritis symptoms when injected into the joints of rats.
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Scientists have linked rheumatoid arthritis development to the excess production of reactive oxygen species (ROS). ROS can oxidize and degrade cartilage and bone, as well as activate the expression of inflammatory cytokines. ....

Yingjia Li , Yingfeng Tu , Emily Henderson , Fei Peng , Nano Letters , Rheumatoid Arthritis , Anti Inflammatory , Joint Pain , எமிலி ஹென்டர்சன் , ஃபெ பெங் , நானோ எழுத்துக்கள் , முடக்கு கீல்வாதம் , எதிர்ப்பு அழற்சி , கூட்டு வலி ,