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Battling arthritis, Nick a great leader with ton of courage


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WHEN you score a masterful l78 at this stage of your career, you can t be batting too badly.
That is especially the case when you have to deal with arthritis and are captain of a talented young side that needs an experienced hand to guide them.
Ipswich Hornets Second Grade captain Nick De Giusti is doing just that in this year s Allan Pettigrew Shield competition.
De Giusti s fine 249 ball knock against Redlands at Wellington Point last weekend left him understandably sore after holding the team s innings together.
It was pretty good. I come in when the team sort of needed it, he said, batting at number four and having wickets fall around him. ....

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Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases


Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases
Autoimmune diseases, in which the body s own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities.
The immune system can be a mixed blessing: Usually it is highly effective in protecting the human organism against bacteria, viruses and mycosis and even cancer. But these defense cells can also turn against the body s own tissues and trigger autoimmune diseases, including for example rheumatoid arthritis and systemic lupus erythematosus, an illness involving chronic dermatitis and inflammation of the joints, the nervous system and internal organs or even become cancer cells themselves and dev ....

Maike Buchner , Juergen Ruland , Emily Henderson , Technical University Of Munich , German Research Foundation , Institute Of Clinical Chemistry , Institute For Clinical Chemistry , Technical University , Clinical Chemistry , Research Foundation , Leibniz Prize , Receptor Activator , Autoimmune Disease , Immune System , Lupus Erythematosus , Nervous System , Rheumatoid Arthritis , Systemic Lupus Erythematosus , ஜூர்கன் ருளந்ட் , எமிலி ஹென்டர்சன் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , நிறுவனம் ஆஃப் மருத்துவ வேதியியல் , நிறுவனம் க்கு மருத்துவ வேதியியல் , தொழில்நுட்ப பல்கலைக்கழகம் , மருத்துவ வேதியியல் ,

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients


SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), is associated with several clinical features common in autoimmune diseases as myalgias, arthralgias, fatigue, and rashes. COVID-19 patients also exhibit less common autoimmunity manifestations such as myositis, thrombosis, myocarditis, encephalitis, vasculitis, and arthritis.
These observations, coupled with the increasing number of recovered long-COVID patients with post-COVID-19 symptoms, indicate that SARS-CoV-2-related inflammation promotes tissue damage. Prior research has shown that about 50% of hospitalized COVID-19 patients at an academic hospital in Greece had high serum levels of autoantibodies, often associated with thrombosis, rashes, and vasculitis. Also, serum anti-nuclear antibodies (ANAs) were detected in about one-third of the patients. ....

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