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Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion. ....
Insights into elusive protein complex can help find novel treatments for chromosomal disorders The cells in our body are constantly fighting off the threat of cancer by repairing damaged DNA. In a new study, scientists from Tokyo University of Science investigate the structure of an elusive protein complex that plays a key role in the activation of the Fanconi anemia pathway involved in DNA repair, and report on the factors governing its stability. Their insights can potentially help find novel treatments for disorders involving chromosomal instability, including cancer. One of the most vital functions performed by the cells in our body is DNA repair, a task so crucial to our well-being that failing to execute it can lead to consequences as dreadful as cancer. The process of DNA repair involves a complex interplay between several gene pathways and proteins. ....
VEXAS syndrome in men is more common than previously thought A rare disease first identified in 2020 is much more common than first thought, say researchers at the University of Leeds investigating its origins. VEXAS syndrome is a serious inflammatory condition which develops in men over 50, causing them to become very sick and fatigued, and can be fatal. It was originally thought to be rare, but a new study has identified genetic mutations which indicate that the disease is actually much more common. The researchers developed a genetic test to identify patients who may have the disease, and now want to screen more people showing symptoms to understand exactly how common it is. ....
Genetic variation associated with COVID-19 outcome The severity of outcome from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is widely varied, with most individuals remaining asymptomatic while others experience severe life-threatening pneumonia and multi-organ failure. Host genetics play a role in disease progression and prognosis. A paper recently uploaded to the preprint server et al. (1 st March 2021) identifies several alleles associated with the gene natriuretic peptide receptor C (NPR3) that may impact disease severity. How was the study performed? The group worked with 4,488 high-risk COVID-19 outpatients being over 40 years of age and having at least one other comorbidity such as diabetes or obesity. The group was split into two equal sizes, one of which received a placebo, while the other received 0.5 mg colchicine, an anti-inflammatory, daily for a month. The patients were evaluated for disease symptoms 15 and 30 days into ....