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Kojin Therapeutics Debuts to Solve Difficult Diseases Through Cell Behavior


Published: Jun 09, 2021
By Mark Terry
Kojin Therapeutics
launched with a $60 million Series A to initially focus on oncology and cell state biology. The round was led by Polaris Partners, Newpath Partners, and Cathay Health, affiliated to Cathay Capital. Participants included Leaps by Bayer, AbbVie, Eventide Asset Management, Alexandria, the Dana-Farber Cancer Institute’s Binney Street Capital, and several family offices.
The approach came out of the
laboratoryof Stuart Schreiber, Harvard University professor and co-founder of the Broad Institute. Co-founders of Kojin include Benjamin Cravatt, Stephanie Dougan and Vasanthi Viswanathan. The company’s technology is ferroptosis-based drug discovery, which is to say, iron-dependent cell death. Kojin says that difficult-to-treat diseases, which includes drug-resistant cancers, involve diseased cells that are sensitive to ferroptosis. ....

United States , Al Iskandariyah , Harvard University , Dana Farber Cancer Institute , Jurgen Eckhardt , Amir Nashat , Benjamin Cravatt , Stephanie Dougan , Joel Barrish , Steve Davidsen , Nagesh Mahanthappa , Susan Langer , Vasanthi Viswanathan , Nortonb Gilula , Stuart Schreiber , Kay Ahn , Sean Morrison , Scripps Research Institute , Broad Institute , Sarcoma Center At Dana Farber , Harvard Medical School , Ludwig Center At Dana Farber Harvard Cancer , Cathay Health , Children Medical Center Research Institute , Department Of Chemistry , Schreiber Lab ,

'Jumping' genes can prevent blood cancers: Study


Jumping genes can prevent blood cancers: Study
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IANS
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Gallbladder, biliary tract cancer cases up 76% in 3 decades. Image Source: IANS News
New York, April 9 : US scientists have found that transposons, also known as jumping genes, can protect against certain blood cancers and help develop new therapeutic targets.
Transposons are DNA sequences that can move, or jump, from one location in the genome to another when activated. These jumping genes are a source of genetic mutations responsible for a number of human diseases.
The findings, published in the journal Nature Genetics, can help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML) the deadliest type of blood cancer in adults and children. ....

New York , United States , Jian Xu , Children Medical Center Research Institute , University Of Texas Southwestern , Nature Genetics , Medical Center Research Institute , Texas Southwestern , Associate Professor , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஜியான் ஐயூ , குழந்தைகள் மருத்துவ மையம் ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் தென்மேற்கு , இயற்கை ஜெநெடிக்ஸ் , மருத்துவ மையம் ஆராய்ச்சி நிறுவனம் , டெக்சாஸ் தென்மேற்கு , இணை ப்ரொஃபெஸர் ,

Scientists discover 'jumping' genes that can protect against blood cancers


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IMAGE: Zhimin Gu, Ph.D., postdoctoral fellow, Children s Medical Center Research Institute at UT Southwestern (CRI), and Jian Xu Ph.D., associate professor, CRI
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Credit: UT Southwestern Medical Center
DALLAS - April 8, 2021 - New research has uncovered a surprising role for so-called jumping genes that are a source of genetic mutations responsible for a number of human diseases. In the new study from Children s Medical Center Research Institute at UT Southwestern (CRI), scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against certain blood cancers.
These findings, published in
Nature Genetics, led scientists to identify a new biomarker that could help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML), the deadliest type of blood cancer in adults and children. ....

United States , Yuxuan Liu , Alec Zhang , Jian Xu , John Abrams , Zhimin Gu , Scholar In Cancer Research , National Institutes Of Health , Children Medical Center Dallas , Leukemia Texas Foundation , American Society Of Hematology Scholar , Welch Foundation , Children Medical Center Research Institute , Ut Southwestern Medical Center , Children Medical Center Foundation , Leukemia Lymphoma Society Scholar , Children Health , Research Institute Of Texas , Dakota State University , Medical Center Research Institute , Nature Genetics , Cancer Prevention , Research Institute , South Dakota State , National Institutes , Lymphoma Society Scholar ,