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Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study


Nicotinamide adenine dinucleotide (NAD
+) is pivotal to physiological processes, not only as the coenzyme of cellular oxidation–reduction reactions but also for the activation of NAD
+-consuming enzymes, such as sirtuins, poly-ADP-ribose polymerases (PARPs), cADP-ribose synthases, NADase (CD38), and mono-ADP-ribose transferases (ARTs) [1]. NAD
+ participates in more than 50% of all physiological processes, including mitochondrial biogenesis, cardiovascular protection, neuroprotection, oxidative stress, DNA damage repair, stem cell rejuvenation, and inflammation [2]. Low NAD
+ levels are associated with age-associated physical disability and diseases, such as metabolic syndrome and cardiovascular disease [1,2,3]. The NAD
+ salvage pathway, which utilizes NAD
+ precursors, is the predominant mechanism for maintaining cellular NAD ....

Ergoline Ergoselect , Guangzhou Sport University , Geneharbor Hong Kong Biotechnologies Ltd , Health Promotion Of Guangzhou Sport University , Key Laboratory , Health Promotion , Guangzhou Pearl River , Chinese Clinical Trial Registry , Hong Kong , Garmin Forerunner , Cardiopulmonary Exercise Testing , குவாங்சோ விளையாட்டு பல்கலைக்கழகம் , விசை ஆய்வகம் , ஆரோக்கியம் ப்ரமோஶந் , சீன மருத்துவ சோதனை பதிவு , ஹாங் காங் , கார்மின் முன்னோடி , இருதய நுரையீரல் உடற்பயிற்சி சோதனை ,