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Novel Gene Identified as Genetic Cause of Portal Hypertension


May 06, 2021
by Julie Parry
The liver serves many critical functions within the human body, including the production of critical proteins, and the removal of waste and toxins. But when damage occurs to the largest organ in the body, many people do not experience symptoms until serious damage has occurred. When the liver becomes scarred, blood can collect and raise the pressure of the portal vein. This accumulation causes portal hypertension and can lead to fluid build up in the abdomen and other detrimental side effects, including death.
In new research published in the
Journal of Experimental Medicine, the research team led by Silvia Vilarinho, MD, PhD, assistant professor of medicine (digestive diseases), and of pathology, performed genomic analysis to determine the cause of unexplained portal hypertension in four unrelated families. ....

South Korea , Joseph Brancale , Richardp Lifton , Silvia Vilarinho , Junhui Zhang , Dhanpat Jain , Isil Berat Barlan Center , Korea University College Of Medicine , National Institutes Of Health , Research Hospital , Marmara University School Of Medicine , Rockefeller University , Laboratory Of Human Genetics , Child Health , Gazi University , Experimental Medicine , Kaela Drzewiecki , Korea University College , National Institutes , Sami Ulus Maternity , Diseases Training , Marmara University School , Translational Medicine , Cleveland Clinic Children , Human Genetics , தெற்கு கொரியா ,

Low HDL Tied to Parkinson's Disease | Physician's Weekly


Feb 10, 2021
Longitudinal study is first to explore HDL variability and PD
Lower high density lipoprotein (HDL) cholesterol levels and greater HDL variability were associated with higher incidence of Parkinson’s disease (PD), a large, nationwide, population-based, longitudinal study in Korea found.
In this study, “baseline HDL-C level, mean HDL-C level, and HDL-C variability was associated with the risk of PD incidence, regardless of potential confounding factors,” wrote Do-Hoon Kim, MD, of Korea University College of Medicine, Ansan, and co-authors in
“HDL has reverse cholesterol transport and a wide range of other functions, including anti-oxidation, anti-inflammation, pro-endothelial function, anti-thrombosis, and modulation of immune function,” they noted. “Because oxidative stress and chronic inflammation may be associated with PD, HDL reduction can affect the development of PD.” ....

South Korea , Kangwon Do , Gian Pietro Sechi , Paul Smyth , Hoon Kim , Korea Medical Institute , Korea University College Of Medicine , Korea University Ansan Hospital , University Of Sassari , Korea National Health Insurance System , Do Hoon Kim , Korea University College , National Health Insurance System , Contributing Writer , Korea Medical , தெற்கு கொரியா , பால் ஸ்மித் , ஹூன் கிம் , கொரியா மருத்துவ நிறுவனம் , கொரியா பல்கலைக்கழகம் கல்லூரி ஆஃப் மருந்து , கொரியா பல்கலைக்கழகம் அன்சன் மருத்துவமனை , கொரியா தேசிய ஆரோக்கியம் காப்பீடு அமைப்பு , செய் ஹூன் கிம் , கொரியா பல்கலைக்கழகம் கல்லூரி , தேசிய ஆரோக்கியம் காப்பீடு அமைப்பு , கொரியா மருத்துவ ,