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Common Antibiotics Spell Trouble in Existing Aortopathy

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For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study.
In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) were at higher risk of adverse outcomes during the periods they were exposed to fluoroquinolones:
All-cause death: adjusted HR 1.61 (95% CI 1.50-1.73)
Aortic death: adjusted HR 1.80 (95% CI 1.50-2.15)
Aortic open surgery: adjusted HR 1.49 (95% CI 1.24-1.79)
Aortic stent placement: adjusted HR 1.64 (95% CI 1.30-2.06)
By contrast, amoxicillin (Amoxil) exposure was not associated with any of these outcomes over follow-up averaging 3.5 years, according to Shao-Wei Chen, MD, PhD, of Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan, and colleagues. ....

United States , Baylor College Of Medicine , Tainan Municipality , Chang Gung Memorial Hospital , Taoyuan Xian , Scott Lemaire , Coll Cardiol , Nicole Lou , Shao Wei Chen , Chang Gung University , Taiwan National Health Insurance Research Database , Journal Of The American College Cardiology , European Medicines Agency , Linkou Medical Center , Taoyuan City , American College , Baylor College , Taiwan National Health Insurance Research , Medpage Today , Aortic Aneurysm , Loeys Dietz Syndrome , Marfan Syndrome , Torsade De Pointes , Disorder Of Connective Tissue , ஒன்றுபட்டது மாநிலங்களில் , பேலர் கல்லூரி ஆஃப் மருந்து ,

First-Ever Survival Bump in Relapsed Mesothelioma

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Patients with progressive mesothelioma obtained a first-ever survival improvement with nivolumab (Opdivo) as second-line therapy, a randomized trial showed.
Median overall survival (OS) increased by almost 40%, and the progression-free interval also improved significantly with the immune checkpoint inhibitor as compared with placebo. In particular, a significant clinical benefit was evidence in patients with epithelioid subtype, the predominant mesothelioma histology.
PD-L1 expression status did not influence response to treatment, although only a third of patients tested positive for the biomarker, reported Dean Fennell, MD, of the University of Leicester in England, at the virtual World Conference on Lung Cancer. ....

New South Wales , Rina Hui , University Of Leicester , Crown Princess Mary Cancer Center , University Of Sydney , Dean Fennell , World Conference , Disorder Of Connective Tissue , Malignant Neoplastic Disease , Mass Of Pelvic Structure , Abdominal Mass , Neoplasm Of Pelvis , புதியது தெற்கு வேல்ஸ் , ரின ஹுய் , பல்கலைக்கழகம் ஆஃப் லெய்செஸ்டர் , கிரீடம் ப்ரிந்ஸெஸ் மேரி புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் சிட்னி , டீன் ஃபெநல் , உலகம் மாநாடு , கோளாறு ஆஃப் இணைப்பு திசு , நிறை ஆஃப் இடுப்பு அமைப்பு , அடிவயிற்றைச் சார்ந்த நிறை ,