email article For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study. In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) were at higher risk of adverse outcomes during the periods they were exposed to fluoroquinolones: All-cause death: adjusted HR 1.61 (95% CI 1.50-1.73) Aortic death: adjusted HR 1.80 (95% CI 1.50-2.15) Aortic open surgery: adjusted HR 1.49 (95% CI 1.24-1.79) Aortic stent placement: adjusted HR 1.64 (95% CI 1.30-2.06) By contrast, amoxicillin (Amoxil) exposure was not associated with any of these outcomes over follow-up averaging 3.5 years, according to Shao-Wei Chen, MD, PhD, of Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan, and colleagues.