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Common Antibiotics Spell Trouble in Existing Aortopathy

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For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study.
In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) were at higher risk of adverse outcomes during the periods they were exposed to fluoroquinolones:
All-cause death: adjusted HR 1.61 (95% CI 1.50-1.73)
Aortic death: adjusted HR 1.80 (95% CI 1.50-2.15)
Aortic open surgery: adjusted HR 1.49 (95% CI 1.24-1.79)
Aortic stent placement: adjusted HR 1.64 (95% CI 1.30-2.06)
By contrast, amoxicillin (Amoxil) exposure was not associated with any of these outcomes over follow-up averaging 3.5 years, according to Shao-Wei Chen, MD, PhD, of Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan, and colleagues. ....

United States , Baylor College Of Medicine , Tainan Municipality , Chang Gung Memorial Hospital , Taoyuan Xian , Scott Lemaire , Coll Cardiol , Nicole Lou , Shao Wei Chen , Chang Gung University , Taiwan National Health Insurance Research Database , Journal Of The American College Cardiology , European Medicines Agency , Linkou Medical Center , Taoyuan City , American College , Baylor College , Taiwan National Health Insurance Research , Medpage Today , Aortic Aneurysm , Loeys Dietz Syndrome , Marfan Syndrome , Torsade De Pointes , Disorder Of Connective Tissue , ஒன்றுபட்டது மாநிலங்களில் , பேலர் கல்லூரி ஆஃப் மருந்து ,

Autism May Raise Risk for Substance Use Disorder

Jan 12, 2021
MONDAY, Jan. 11, 2021 (HealthDay News) Individuals with autism spectrum disorder (ASD) have an increased risk for substance use disorder (SUD), according to a study published online Jan. 4 in
JAMA Pediatrics.
Jing-Syuan Huang, M.D., from the National Defense Medical Center in Taipei, Taiwan, and colleagues examined the risk for SUD in patients with ASD and its associations with comorbidities, psychotropic agents (PAs), and mortality in a retrospective cohort study of participants from the Taiwan National Health Insurance Research Database. Overall, 6,599 individuals with ASD (mean age, 11.9 years) and 26,396 controls (mean age, 12.1 years) were enrolled.
The researchers found that compared with controls, the ASD group had significantly increased risks for SUD, alcohol use disorder (AUD), and drug use disorder (DUD), with adjusted hazard ratios of 2.33, 2.07, and 3.00, respectively, in a multivariable-adjusted analysis. In ASD subgroups with one PA a ....

T Ai Pei , Jing Syuan Huang , Taiwan National Health Insurance Research Database , National Defense Medical Center , Healthday News , Syuan Huang , Taiwan National Health Insurance Research , டி ஐ பேய் , டைவாந் தேசிய ஆரோக்கியம் காப்பீடு ஆராய்ச்சி தரவுத்தளம் , தேசிய பாதுகாப்பு மருத்துவ மையம் , டைவாந் தேசிய ஆரோக்கியம் காப்பீடு ஆராய்ச்சி ,