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For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study.
In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) were at higher risk of adverse outcomes during the periods they were exposed to fluoroquinolones:
All-cause death: adjusted HR 1.61 (95% CI 1.50-1.73)
Aortic death: adjusted HR 1.80 (95% CI 1.50-2.15)
Aortic open surgery: adjusted HR 1.49 (95% CI 1.24-1.79)
Aortic stent placement: adjusted HR 1.64 (95% CI 1.30-2.06)
By contrast, amoxicillin (Amoxil) exposure was not associated with any of these outcomes over follow-up averaging 3.5 years, according to Shao-Wei Chen, MD, PhD, of Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan, and colleagues. ....

United States , Baylor College Of Medicine , Tainan Municipality , Chang Gung Memorial Hospital , Taoyuan Xian , Scott Lemaire , Coll Cardiol , Nicole Lou , Shao Wei Chen , Chang Gung University , Taiwan National Health Insurance Research Database , Journal Of The American College Cardiology , European Medicines Agency , Linkou Medical Center , Taoyuan City , American College , Baylor College , Taiwan National Health Insurance Research , Medpage Today , Aortic Aneurysm , Loeys Dietz Syndrome , Marfan Syndrome , Torsade De Pointes , Disorder Of Connective Tissue , ஒன்றுபட்டது மாநிலங்களில் , பேலர் கல்லூரி ஆஃப் மருந்து ,