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Scientists find 2 species of human coronavirus that can evolve to evade immune system


Scientists find 2 species of human coronavirus that can evolve to evade immune system
January 21, 2021
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The findings suggest that if SARS-CoV-2 evolves in the same way, current vaccines against the virus may become outdated
A new study has found that two species of seasonal human coronavirus related to SARS-CoV-2 can evolve in certain proteins to evade recognition by the immune system.
The findings of the study, published in the journal
eLife, suggested that if SARS-CoV-2 evolves in the same way, current vaccines against the virus may become outdated, requiring new ones to be made to match future strains.
The researchers mentioned that the immune system relies on being able to ‘remember’ the antigens that relate to a specific virus in order to provide immunity against it. ....

Kathryn Kistler , Infectious Disease Division , Fred Hutchinson Cancer Research Center , Spike Protein , Corona Virus , Covid 19 , Sars Cov 2 , க்யாத்ரிந் கிஸ்ட்லர் , தொற்று நோய் பிரிவு , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி மையம் , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , சர்வதேச பரவல் ,

Seasonal Coronaviruses' Spike Proteins Evolve to Evade Immune Responses


Seasonal Coronaviruses’ Spike Proteins Evolve to Evade Immune Responses
3D print of a spike protein of SARS-CoV-2—also known as 2019-nCoV, the virus that causes COVID-19—in front of a 3D print of a SARS-CoV-2 virus particle. The spike protein (foreground) enables the virus to enter and infect human cells. On the virus model, the virus surface (blue) is covered with spike proteins (red) that enable the virus to enter and infect human cells. [NIH]
January 20, 2021
The appearance of SARS-CoV-2 variants has permeated the news since the beginning of the year. Viruses mutate, so new variants are not surprising. But the phenotypes associated with those changes could potentially be a cause of concern; particularly if they impact immune memory or vaccine efficacy. Now, scientists address the influence of antigenic drift (slow mutational changes over time) on immune evasion of seasonal coronaviruses. In doing so, they show that two seasonal human coronaviruses un ....

Trevor Bedford , Kathryn Kistler , Infectious Disease Division , Fred Hutchinson Cancer Research Center , Fred Hutchinson Cancer Research , ட்ரெவர் பெட்ஃபோர்ட் , க்யாத்ரிந் கிஸ்ட்லர் , தொற்று நோய் பிரிவு , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி மையம் , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி ,

Spike proteins of SARS-CoV-2 relatives can evolve against immune responses


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Scientists have shown that two species of seasonal human coronavirus related to SARS-CoV-2 can evolve in certain proteins to escape recognition by the immune system, according to a study published today in
eLife.
The findings suggest that, if SARS-CoV-2 evolves in the same way, current vaccines against the virus may become outdated, requiring new ones to be made to match future strains.
When a person is infected by a virus or vaccinated against it, immune cells in their body will produce antibodies that can recognise and bind to unique proteins on the virus surface known as antigens. The immune system relies on being able to remember the antigens that relate to a specific virus in order to provide immunity against it. However, in some viruses, such as the seasonal flu, those antigens are likely to change and evolve in a process called antigenic drift, meaning the immune system may no longer respond to reinfection. ....

Trevor Bedford , Claire Hudson , Emily Packer , Kathryn Kistler , Infectious Disease Division , Fred Hutchinson Cancer Research Center , Principal Investigator , Associate Member , Fred Hutchinson Cancer Research , Media Relations Manager , Communications Manager , Hutchinson Cancer Research Center , ட்ரெவர் பெட்ஃபோர்ட் , கிளாரி ஹட்சன் , எமிலி ப்யாகர் , க்யாத்ரிந் கிஸ்ட்லர் , தொற்று நோய் பிரிவு , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி மையம் , ப்ரிந்ஸிபல் புலனாய்வாளர் , இணை உறுப்பினர் , ஃப்ரெட் ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி , மீடியா உறவுகள் மேலாளர் , தகவல்தொடர்புகள் மேலாளர் , ஹட்சின்சன் புற்றுநோய் ஆராய்ச்சி மையம் ,