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Watchdog organization alleges WSU research staff fabricated data, overdosed animals, violated protocols

Watchdog organization alleges WSU research staff fabricated data, overdosed animals, violated protocols
dailyevergreen.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dailyevergreen.com Daily Mail and Mail on Sunday newspapers.

Heiko Jansen , Kathryn Bayne , Kirk Schulz , Ryan Evanoff , Alan Ekstrand , Michael Budkie , Christopher Keane , Axel Wolff , Phil Weiler , Washington State University , Animal Welfare Program , Department Of Integrative Physiology , Accreditation Of Laboratory Animal Care International , Association For Assessment , Office Of Research Integrity , Stop Animal Explotation Now , National Institutes , Laboratory Animal Welfare , Stop Animal Exploitation Now , State University , Director Michael Budkie , Daily Evergreen , Animal Welfare Act , Retraction Watch , Research Integrity , Equine Veterinary Journal ,

Donna Sheperis

Donna Sheperis
theconversation.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theconversation.com Daily Mail and Mail on Sunday newspapers.

United States , Palo Alto , Donna Sheperis , Research In Counseling , Association For Humanistic Counseling , Board Certified Telemental Health Provider , Delta State University , Clinical Mental Health Counseling , Institutional Review Board At Palo Alto University , University Of Mississippi , Association For Counselor Education , Board Certified Clinical Mental Health Counselor , Ethics Committee , Association For Assessment , Faculty Senate , Associate Chair , Clinical Training , Institutional Review Board , Counselor Education , Delta State , Licensed Professional Counselor , Board Certified Counselor , Approved Clinical Supervisor , Ethics Appeals Committee , American Counseling , Humanistic Counseling ,

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Globally, there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21). Using Syrian hamsters that model moderate to severe COVID-19 disease, we demonstrate the high efficacy of PiN-21 to prevent and treat SARS-CoV-2 infection. Intranasal delivery of PiN-21 at 0.6 mg/kg protects infected animals from weight loss and substantially reduces viral burdens in both lower and upper airways compared to control. Aerosol delivery of PiN-21 facilitates deposition throughout the respiratory tract and dose minimization to 0.2 mg/kg. Inhalation treatment quickly reverses animals’ weight loss after infection, decreases lung viral titers by 6 logs leading to drastically mitigated lung pathology, and prevents viral pneumonia. Combined with the marked stability and low production cost, this innovative therapy may provide a convenient and cos ....

United States , Sakura Finetek , Akoya Biosciences , Economic Development , Accreditation Of Laboratory Animal Care , Commonwealth Of Pennsylvania Department Community , Henryl Hillman Foundation , University Of Pittsburgh , Richard King Mellon Foundation , Vaccine Research , Association For Assessment , Laboratory Animals , National Institutes Of Health , University Of Pittsburgh Center , University Of Pittsburgh Institutional Animal Care , Public Health Services Policy On Humane Care , Regional Biocontainment Laboratory , Zymo Research , Using Syrian , Laboratory Animal , National Institutes , Animal Welfare Act , Public Health Services Policy , Humane Care , Pittsburgh Institutional Animal Care , Use Committee ,

An oral antisense oligonucleotide for PCSK9 inhibition

Strategies to decrease low-density lipoprotein (LDL) cholesterol could help treat atherosclerosis. Here, Gennemark et al . developed an antisense oligonucleotide (ASO) that can be delivered orally, is taken up by the liver, and targets PCSK9, which regulates the LDL receptor. Subcutaneous administration of the ASO showed high potency in mice overexpressing PCSK9, a liver half-life of 18 days in monkeys, and reduced circulating PCSK9 in humans. The oral formulation showed 5 to 7% liver bioavailability compared to subcutaneous administration in rats and dogs, and it reduced LDL cholesterol in healthy monkeys. Results support the potential of this ASO for PCSK9 inhibition while avoiding the need for injections.

Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce low-density lipoprotein (LDL) cholesterol and are used for treatment of dyslipidemia. Current PCSK9 inhibitors are administered via subcutaneous injection. We present a highly potent, chemically modif ....

Taconic Biosciences Inc , Accreditation Of Laboratory Animal Care International , Ionis Pharmaceuticals , Association For Assessment , Taconic Biosciences , Beckman Coulter , Thermo Fisher Scientific , Charles River , Laboratory Animal Care International , Abbot Scandinavia , Horiba Medical , டகோனிக் உயிர் அறிவியல் இன்க் , அங்கீகாரம் ஆஃப் ஆய்வகம் விலங்கு பராமரிப்பு சர்வதேச , சங்கம் க்கு மதிப்பீடு , டகோனிக் உயிர் அறிவியல் , பெக்மேன் கூல்டர் , தெர்மோ மீனவர் அறிவியல் , சார்லஸ் நதி , ஆய்வகம் விலங்கு பராமரிப்பு சர்வதேச , ஹொரிபா மருத்துவ ,

Vyant Bio Announces Newly Appointed Board of Directors

Vyant Bio Announces Newly Appointed Board of Directors
streetinsider.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from streetinsider.com Daily Mail and Mail on Sunday newspapers.

United States , Andy Lafrence , Howard Mcleod , Vyant Bio , Jay Roberts , John Fletcher , Marcusf Boehm , Paul Hansen , Jenniferk Zimmons , Joanna Horobin , Geoffrey Harris , Vyant Biodate , University Of Minnesota Technological Leadership Institute , Molesafe Inc , Idera Pharmaceuticals Inc , Celgene Corporation , Department Of Individualized Cancer Management , Eshelman School Of Pharmacy , Debartolo Family Personalized Medicine Institute , Fletcher Spaght Inc , Vyant Bio Inc , Telemynd Inc , Conforma Therapeutics Corporation , Taneja College Of Pharmacy , Accreditation Of Laboratory Animal Care International , M Company ,