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Zymo Research Introduces A New Graduate Student Starter Pack for Life Science Researchers

/PRNewswire/ -- Zymo Research Corp., a leader in biotechnology innovation, has unveiled the company's 'Graduate Student Starter Pack'. This new program is...

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Zymo Research Introduces A New Graduate Student Starter Pack for Life Science Researchers

Zymo Research Introduces A New Graduate Student Starter Pack for Life Science Researchers
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Fontan circulation link to changes in the genetic code may lead to new treatment for heart conditions

Fontan circulation link to changes in the genetic code may lead to new treatment for heart conditions
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California , United-states , United-kingdom , Nigel-drury , Nigele-drury , Zymo-research , University-of-birmingham , Associate-clinical-professor , Accelerated-epigenetic-aging , Adults-with , Fontan-circulation ,

Nucleic Acid Sample Preparation Market Global and Regional Analysis 2023-2033: Increasing Demand for Reliable Next-Generation Sequencing (NGS) Platforms in Clinical Laboratories

/PRNewswire/ -- The "Nucleic Acid Sample Preparation Market - A Global and Regional Analysis: Focus on Technology, Application, Product, End User, and Country...

Dublin , Ireland , Canada , China , United-states , Japan , America , Chinese , Norgen-biotek , Omega-bio-tek , Takara-bio , Laura-wood

DNA/RNA Sample Extraction and Isolation Market Report- Expansive Coverage on the Profit Sources

DNA/RNA Sample Extraction and Isolation Market Report- Expansive Coverage on the Profit Sources
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Germany , France , Mexico , South-africa , South-korea , Brazil , Canada , United-kingdom , Argentina , United-states , American , America

Hemostasis Analyzers Global Market Report 2024 - Hemostasis Analyzers Market Flourishes as Aging Population and Chronic Diseases Propel Demand

/PRNewswire/ -- The "Hemostasis Analyzers Global Market Report 2024" has been added to ResearchAndMarkets.com's offering. The research publication on the...

Dublin , Ireland , Russia , United-states , American , Russian , Laura-wood , Transasia-bio , Beckman-coulter-inc , Diagnostica-stago-inc , Rising-global-health-awareness , Trinity-biotech

Hemostasis Analyzers Global Market Report 2024 - Hemostasis Analyzers Market Flourishes As Aging Population And Chronic Diseases Propel Demand

Hemostasis Analyzers Global Market Report 2024 - Hemostasis Analyzers Market Flourishes As Aging Population And Chronic Diseases Propel Demand
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United-states , Russia , Dublin , Ireland , American , Russian , Transasia-bio , Laura-wood , Office-hours-call , Becton-dickinson , International-technidyne-corporation , Beckman-coulter-inc

Microglial cell response to experimental periodontal disease | Journal of Neuroinflammation

Microglial activation is critical for modulating the neuroinflammatory process and the pathological progression of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglia are involved in forming barriers around extracellular neuritic plaques and the phagocytosis of β-amyloid peptide (Aβ). In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells. Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Maxillary bone loss and local periodontal tissue inflammation associated with the development of PD were confirmed by morphometric bone analysis and cytokine expression, respectively. The frequency and the total number of activated microglia (CD45+ CD11b+ MHCII+) in the brain were analyzed by flow cytometry. Mouse microglial cells (1 × 105) were incubated with heat-inactivated bacterial biofilm isolated from the ligatures retrieved from the teeth or with Klebsiella variicola, a relevant PD-associated bacteria in mice. Expression of pro-inflammatory cytokines, toll-like receptors (TLR), and receptors for phagocytosis was measured by quantitative PCR. The phagocytic capacity of microglia to uptake β-amyloid was analyzed by flow cytometry. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation (p < 0.05) and continued to increase until day 30 (p < 0.0001). The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36%. In parallel, heat-inactivated PD-associated total bacteria and Klebsiella variicola increased the expression of TNFα, IL-1β, IL-6, TLR2, and TLR9 in microglial cells (1.6-, 83-, 3.2-, 1.5-, 1.5-fold, respectively p < 0.01). Incubation of microglia with Klebsiella variicola increased the Aβ-phagocytosis by 394% and the expression of the phagocytic receptor MSR1 by 33-fold compared to the non-activated cells (p < 0.0001). We showed that inducing PD in mice results in microglia activation in vivo and that PD-associated bacteria directly promote a pro-inflammatory and phagocytic phenotype in microglia. These results support a direct role of PD-associated pathogens in neuroinflammation.

Fiji , United-states , Italy , La-jolla , California , Fremont , San-diego , Canada , Miltenyi-biotec , Dnasei-zymo-research , Hbss-rd-systems-inc , Sigma-aldrich

Coherent Market Insights: Global Metagenomic Sequencing Market to Reach US$ 4.39 Billion by 2030, Rising at a CAGR of 17.6%

Coherent Market Insights: Global Metagenomic Sequencing Market to Reach US$ 4.39 Billion by 2030, Rising at a CAGR of 17.6%
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Russia , India , United-states , South-korea , Germany , Australia , South-africa , Brazil , Canada , Mexico , France , Japan

Global Metagenomic Sequencing Market to Reach US$ 4.39 Billion by 2030, Rising at a CAGR of 17.6%

/PRNewswire/ -- CoherentMI published a report, titled, Global Metagenomic Sequencing Market estimated value at US$ 1.41 Billion in the year 2023 and is...

Canada , Mexico , Brazil , France , Japan , India , United-states , Russia , South-africa , Germany , South-korea , Australia