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'Minibrains' With A Neanderthal Gene Offer Hints About Human Evolution


Fossils offer a detailed record of early human skulls but not the brains inside them.
So researchers have been using genetic material taken from those fossils to search for clues about how the human brain has evolved over hundreds of thousands of years.
And now they have succeeded in growing human brain organoids, or minibrains, that contain the Neanderthal variant of a gene called NOVA1, a team reports in the journal
Science.
The archaic version of the gene changes the shape of these organoids, says Alysson Muotri, a professor at the University of California, San Diego and the Sanford Consortium for Regenerative Medicine. Instead of growing into a sphere with a smooth surface, he says, the Neanderthal organoids have an outermost layer that is uneven. ....

San Diego , United States , Michael Gregory , Alysson Muotri , Karen Berman , University Of California , National Institute Of Mental Health , Sanford Consortium For Regenerative Medicine , Muotri Lab Uc San Diego , Sanford Consortium , East Asian , National Institute , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேல் கிரெகொரி , கரேன் பெர்மன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , தேசிய நிறுவனம் ஆஃப் மன ஆரோக்கியம் , சான்ஃபோர்ட் கூட்டமைப்பு க்கு மீளுருவாக்கம் மருந்து , சான்ஃபோர்ட் கூட்டமைப்பு , கிழக்கு ஆசிய , தேசிய நிறுவனம் ,

How a single gene alteration may have separated modern humans from predecessors


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IMAGE: Neanderthal-ized brain organoids (left) look very different than modern human brain organoids (right) they have a distinctly different shape, and differ in the way their cells proliferate and how.
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Credit: UC San Diego Health Sciences
As a professor of pediatrics and cellular and molecular medicine at University of California San Diego School of Medicine, Alysson R. Muotri, PhD, has long studied how the brain develops and what goes wrong in neurological disorders. For almost as long, he has also been curious about the evolution of the human brain what changed that makes us so different from preceding Neanderthals and Denisovans, our closest evolutionary relatives, now extinct? ....

San Diego , United States , City Of , United Kingdom , University Of California San Diego , National University Of Singapore , Singapore General , Alexandreh Kihara , Stephenep Smith , Assaela Madrigal , Emilyc Wheeler , Kallen Wang , Christopher Vollmers , Beth Shapiro , Clebera Trujillo , Jonathand Lautz , Ryan Szeto , Isaaca Chaim , Mariana Sa Ferraz , Sebastian Preissl , Nathank Schaefer , Justin Buchanan , Ashley Byrne , Priscillad Negraes , Katerina Semendeferi , Alyssonr Muotri ,

UC San Diego reports surge in coronavirus infections among students since return from holidays


UC San Diego reports surge in coronavirus infections among students since return from holidays
UC San Diego says 245 students have tested positive for the COVID-19 coronavirus since Jan. 4.
(File)
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UC San Diego says 245 of its students have tested positive for the COVID-19 coronavirus since the winter quarter began Jan. 4 the kind of surge the university avoided last fall through a major testing and education campaign called “Return to Learn.”
University data show that 109 of those students live at UCSD, which has one of the most comprehensive coronavirus testing programs in academia. The 136 other students are living off campus in the San Diego area. UCSD also said that 61 of its employees have tested positive for the virus. ....

San Diego , United States , San Diego Bay , Research Facility , Sanford Consortium For Regenerative Medicine , Telemedicine Building , Biological Research Facility , Sanford Consortium , Regenerative Medicine , Nimitz Marine Facility , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ வளைகுடா , ஆராய்ச்சி வசதி , சான்ஃபோர்ட் கூட்டமைப்பு க்கு மீளுருவாக்கம் மருந்து , டெலிமெடிசின் கட்டிடம் , உயிரியல் ஆராய்ச்சி வசதி , சான்ஃபோர்ட் கூட்டமைப்பு , மீளுருவாக்கம் மருந்து , நிமிட்ஸ் கடல் வசதி ,