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Vaccine target for devastating livestock disease could change lives of millions


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The first ever vaccine target for trypanosomes, a family of parasites that cause devastating disease in animals and humans, has been discovered by scientists at the Wellcome Sanger Institute. By targeting a protein on the cell surface of the parasite Trypanosoma vivax, researchers were able to confer long-lasting protection against animal African trypanosomiasis (AAT) infection in mice.
The study, published today (26 May 2021) in
Nature, is the first successful attempt to induce apparently sterile immunity against a trypanosome parasite. A vaccine was long thought impossible due to the sophisticated ability of the parasites to evade the host immune system. As well as a strong vaccine target for AAT, the findings raise the possibility of identifying vaccine targets for trypanosome species that cause the deadly human infections sleeping sickness and Chagas disease. ....

United Kingdom , United States , Michael Pearce , Andrew Jackson , Matthew Midgley , Delphine Autheman , Gavin Wright , Simon Clare , Sanger Institute , University Of Glasgow , Wellcome Sanger Institute , University Of Liverpool , University Of York , Agriculture Organisation Of The United Nations , Wellcome Sanger , South America , Agriculture Organisation , United Nations , Agricultural Production Economics , ஒன்றுபட்டது கிஂக்டம் , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேல் பியர்ஸ் , ஆண்ட்ரூ ஜாக்சன் , மேத்யூ மிட்லே , கவின் ரைட் , சிமோன் தெளிவு ,