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A Win for Nivolumab as Preoperative Therapy for Lung Cancer

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Adding the immune checkpoint inhibitor nivolumab (Opdivo) to neoadjuvant chemotherapy dramatically increased pathologic complete response (pCR) in patients with operable lung cancer, a randomized trial showed.
The pCR rate increased from 2.2% with chemotherapy alone to 24.0% with the addition of nivolumab. The between-group difference increased in an analysis limited to patients who had complete resection. Clearance of circulating tumor (ct) DNA during neoadjuvant therapy increased the likelihood of pCR, reported Patrick M. Forde, MD, of the Johns Hopkins Sidney Kimmel Cancer Center in Baltimore, at the American Association for Cancer Research (AACR) virtual meeting.
CheckMate 816 showed a statistically significant improvement in pCR, said Forde. This benefit was consistent across disease stages, histology, TMB (tumor mutational burden) and PD-L1 expression. The study continues to mature for the event-free survival (EFS) primary endpoint. ....

United States , United Kingdom , Patrickm Forde , Charles Bankhead , Charles Swanton , University College London , American Association For Cancer Research , Cancer Research United Kingdom , Johns Hopkins Sidney Kimmel Cancer Center , American Association , Cancer Research , Cancer Research United , Medpage Today , Malignant Tumor Of Lung , Mass Of Body Structure , Neoplastic Disease , Non Small Cell Lung Cancer , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , சார்லஸ் வங்கித் தலை , சார்லஸ் ஸ்வாண்டன் , பல்கலைக்கழகம் கல்லூரி லண்டன் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , புற்றுநோய் ஆராய்ச்சி ஒன்றுபட்டது கிஂக்டம் , ஜான்ஸ் ஹாப்கின்ஸ் சிட்னி கீம்மேல் புற்றுநோய் மையம் , அமெரிக்கன் சங்கம் ,

60 Stocks Moving In Thursday's Mid-Day Session

60 Stocks Moving In Thursday s Mid-Day Session
Benzinga
12/10/2020
Gainers
Immutep Limited (NASDAQ: IMMP) shares jumped 198.6% to $6.42 after the company said its Chinese partner, EOC Pharma will commence a new Phase 2 clinical trial of Immutep s eftilagimod alpha in up to 152 metastatic breast cancer patients in China. Immutep said the study follows encouraging data reported by it in its APIAC Phase 2b study announced at the end of March and presented at the SABCS.
Greenwich LifeSciences, Inc. (NASDAQ: GLSI) shares surged 67.4% to $95.60. Greenwich LifeSciences shares jumped 998% on Wednesday after the company shared the poster for the GP2 Phase 2b clinical trial final efficacy analysis that was presented Wednesday at the 2020 San Antonio Breast Cancer Symposium. ....

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